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|本期目录/Table of Contents|

丙泊酚预处理对大鼠布比卡因中枢及心脏毒性的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第1期
页码:
48-50,55
栏目:
基础研究
出版日期:
2010-01-04

文章信息/Info

Title:
Effects of pretreatment with propofol on bupivacaine-induced systemic toxicities in rats
作者:
周一鸣1; 王强1; 朱萧玲1; 陈绍洋1; 孙炎芫2; 熊利泽1
第四军医大学： 1.西京医院麻醉科；2.口腔医学院麻醉科，陕西 西安 710032
Author(s):
ZHOU Yi-ming;  WANG Qiang;  ZHU Xiao-ling;  CHEN Shao-yang;  SUN Yan-yuan;  XIONG Li-ze
Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China
关键词:
丙泊酚; 预处理; 布比卡因; 毒性
Keywords:
pretreatment;  propofol;  bupivacaine;  toxicity
分类号:
R971. 2
DOI:
-
文献标识码:
A
摘要:
目的: 探讨丙泊酚预处理对大鼠布比卡因中枢神经系统及心脏毒性的影响。方法: 雄性SD大鼠20只随机分为对照组和丙泊酚预处理组，每组各10只，分别于静脉泵注布比卡因前30 min，ip生理盐水10 ml/kg或10 g/L丙泊酚100 mg/kg(10 ml/kg)。以肢体Ⅱ导联监测ECG，暴露大鼠股动脉，置入24G套管针监测动脉血压和备抽取血样，同时暴露大鼠股静脉，置入24G套管针泵入布比卡因。记录各基础参数后，开始用微量注射泵泵入5 g/L布比卡因2 mg/(kg·min)，记录动物发生抽搐、ECG出现心律失常及心搏停止的时间，计算布比卡因在相应时间点的累积剂量。结果: 泵注布比卡因后，丙泊酚预处理组大鼠发生抽搐、心律失常及心搏停止时，布比卡因的累积剂量分别为：(8.9±2.1)mg/kg，(10.5±2.8)mg/kg及(28.0±4.9)mg/kg，均明显大于对照组大鼠的剂量(7.2±2.1)mg/kg，(8.5±2.5)mg/kg及(22.4±3.4)mg/kg(P<0.05)。结论: 丙泊酚预处理可提高大鼠对布比卡因中枢神经及心脏毒性的耐受。
Abstract:
AIM: To evaluate the effect of propofol pretreatment on central nervous system and cardiac toxicities induced by bupivacaine in rats. METHODS: Twenty Sprague Dawley rats were assigned to two groups (n=10 each group). Animals in the control group received 10 ml/kg of saline injection, whereas rats in the propofol pretreatment group received 100 mg/kg (10 ml/kg) of propofol injection IP 30 min before IV infusion of bupivacaine. ECG was continuously monitored. The femoral artery was cannulated for measuring arterial blood pressure and drawing blood samples. The femoral vein was cannulated for the infusion of bupivacaine. After the basic parameters (arterial blood pressure, heart rate and arterial blood gases) were recorded, 5 g/L bupivacaine was infused IV at a rate of 2 mg/(kg·min) to all animals in both groups until asystole. The time of bupivacaine-produced convulsions, QRS prolongation in ECG (arrhythmia) and asystole were recorded. Cumulative dose of bupivacaine was then calculated at the corresponding timepoints. RESULTS: Cumulative doses of bupivacaine that produced convulsions, arrhythmia and asystole in animals pretreated with propofol were (8.9±2.1) mg/kg, (10.5±2.8) mg/kg and (28.0±4.9) mg/kg, respectively, significantly higher than in saline-treated rats (7.2±2.1) mg/kg, (8.5±2.5) mg/kg and (22.4±3.4) mg/kg, respectively (P<0.05). CONCLUSION: Pretreatment with propofol reduces central nervous system and cardiac toxicities of bupivacaine.

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备注/Memo

备注/Memo:
收稿日期：2008-7-16.基金项目：国家自然科学基金项目资助(30570596) 通讯作者：熊利泽，教授，主要从事脏器损伤保护的研究Email: lxiong@fmmu.edu.cn 作者简介：周一鸣，医师，硕士生Email: mazuike@fmmu.edu.cn
更新日期/Last Update: 2010-01-05