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|本期目录/Table of Contents|

Ⅱ型糖尿病并发代谢综合征与心脏自主神经病变的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第2期
页码:
197-199
栏目:
临床研究
出版日期:
2010-03-04

文章信息/Info

Title:
Relationship between metabolic syndrome and cardiac autonomic neuropathy in patients with type Ⅱ diabetes mellitus
作者:
辛苏萍1; 2; 项守奎1; 罗春媛2
1.南京大学医学院临床医学系，江苏 南京 210029；2.武进人民医院内分泌科，江苏 常州 213000
Author(s):
XIN Su-ping1; 2;  XIANG Shou-kui1;  LUO Chun-yuan2
1.Department of Clinical Medicine, Medical School, Nanjing University, Nanjing 210029, Jiangsu, China; 2.Department of Endocrinology, Wujin People’s Hospital, Changzhou 213000, Jiangsu, China
关键词:
糖尿病; Ⅱ型; 代谢综合征; 心脏自主神经病变
Keywords:
type 2 diabetes mellitus;  metabolic syndrome;  cardiac autonomic neuropathy
分类号:
R587.1
DOI:
-
文献标识码:
A
摘要:
目的: 探讨Ⅱ型糖尿病(T2DM)并发代谢综合征（MS）与心脏自主神经病变（CAN）之间的相关性。方法: 根据是否并发MS将438名T2DM患者分为MS组及非MS组，比较两组间CAN发病率的差异，并进行相关及回归分析。结果: MS组的CAN发病率显著高于非MS组，且MS组分与心脏自主神经功能检查得分之间呈正相关；多因素Logistic回归分析显示，糖尿病病程、收缩压、三酰甘油及糖化血红蛋白为CAN发生的高危因素。结论: MS与T2DM的CAN之间密切相关。
Abstract:
AIM: To investigate the relationship between metabolic syndrome (MS) and cardiac autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 438 patients with T2DM were grouped into MS group and non-MS group and the incidence of CAN was compared. Correlation and regression analyses were performed. RESULTS: Patients in MS group had a higher prevalence of CAN than in the non-MS group, and MS features were positively correlated with CAN scores. Diabetic duration, triglycerides, systolic blood pressure and glycosylated hemoglobin were all independent risk factors for CAN. CONCLUSION: MS is significantly associated with CAN in patients with T2DM.

参考文献/References

［1］ Isomaa B, Almgren P, Tuomi T, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome［J］. Diabetes Care, 2001, 24(4):683-689.

［2］ Costa LA, Canani LH, Lisboa HR, et al. Aggregation of features of the metabolic syndrome is associated with increased prevalence of chronic complications in Type 2 diabetes［J］. Diabet Med, 2004, 21(3):252-255.

［3］ Alberti KG, Zimmet P, Shaw J, et al. The metabolic syndrome--a new worldwide definition［J］. Lancet, 2005, 366(9491):1059-1062.

［4］ 赵琳,张霞,王颖,等. 代谢综合征与2型糖尿病慢性并发症的相关性［J］. 中国糖尿病杂志, 2008, 16(5):271-273.

［5］ Bianchi C, Penno G, Daniele G, et al. The metabolic syndrome is related to albuminuria in type 2 diabetes［J］. Diabet Med, 2008, 25(12):1412-1418.

［6］ 干军,冯雨,祝群,等. 2型糖尿病合并代谢综合征与早期糖尿病肾病的相关性［J］. 南京医科大学学报, 2007, 27(2):150-152.

［7］ Bilal N, Erdogan M, Ozbek M, et al. Increasing severity of cardiac autonomic neuropathy is associated with increasing prevalence of nephropathy, retinopathy, and peripheral nuropathy in Turkish type 2 diabetics［J］. J Diabetes Complications, 2008, 22(3):181-185.

备注/Memo

备注/Memo:
收稿日期：2009-4-9.作者简介：辛苏萍，硕士生Email:xsk8012@163.com
更新日期/Last Update: 2010-03-05