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Title:: Effect of aerobic exercise on serum adhesion molecule and C-reactive protein in patients with acute coronary syndrome

作者:: 史建俊¹; ³; 江山²; 刘毅⁴; 董小超⁵; 1.青岛大学医学院心脏内科，山东青岛266021；2．西京医院理疗科，5．西京医院心脏外科，4．第四军医大学病理生理学教研室，陕西西安 710032；3．解放军401医院干部二科，山东青岛 266071

Author(s):: SHI Jian-jun¹; ³; JIANG Shan²; LIU Yi⁴; DONG Xiao-chao⁵; 1.Department of Cardiology, Medical College, Qingdao University, Qingdao 266021, Shandong, China; 2.Department of Physiotherapy, 5.Department of Cardiovascular Surgery, Xijing Hospital, 4.Department of Pathophysiology, Fourth Military Medical Universit

关键词:: 急性冠脉综合征; 有氧运动; 血清黏附分子; C反应蛋白

Keywords:: acute coronary syndrome; aerobic exercise; serum adhesion molecule; C-reactive protein

分类号:: R541.4

DOI:: -

文献标识码:: A

摘要:: 目的: 探讨有氧运动对急性冠脉综合征(ACS)患者可溶性细胞间黏附分子-1(sICAM-1)、血管细胞黏附分子-1(sVCAM-1)和C反应蛋白(CRP)水平的影响。方法: 选取ACS患者70例,将其分为常规治疗组和有氧运动+常规治疗组（加有氧运动组）。另选健康成人为正常对照组。采用酶联免疫吸附法测定各组sICAM-1和sVCAM-1 水平,采用免疫浊度法测定CRP浓度。结果: ACS 患者循环血中sICAM-1、sVCAM-1和CRP水平明显高于正常对照组(P<0.01),两组治疗1个月后sICAM-1、sVCAM-1和CRP水平均较治疗前均明显下降(P<0.05和P<0.01)。且两组各项指标比较,加有氧运动组降低更显著(P<0.05)。结论: ACS 患者血清中sICAM-1、sVCAM-1和CRP水平明显升高,而有氧运动能明显降低ACS患者血中sICAM-1、sVCAM-1和CRP水平。

Abstract:: AIM: To study the effect of aerobic exercise on serum soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cellular adhesion molecule-1 (sVCAM-1) and C-reactive protein (CRP) in patients with acute coronary syndrome (ACS). METHODS: Seventy patients with ACS were divided into two groups: regular treatment group and regular treatment plus aerobic exercise group. Healthy subjects were chosen as the control group. Levels of sICAM-1 and sVCAM-1 were tested by ELISA and the level of CRP was tested by immune turbidimetry. The results were compared. RESULTS: The levels of sICAM-1, sVCAM-1 and CRP in ACS patients were significantly higher than those in the control group (P<0.01). After treatment, the level of sICAM-1, sVCAM-1 and CRP decreased (P<0.05 and P<0.01), especially in the treatment plus aerobic exercise group (P<0.05 and P<0.01). CONCLUSION: The level of sICAM-1, sVCAM-1 and CRP increase in patients with ACS. Aerobic exercise markedly decreases the levels of sICAM-1, sVCAM-1 and CRP.

参考文献/References

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有氧运动对急性冠脉综合征患者血清黏附分子和C反应蛋白的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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