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|本期目录/Table of Contents|

P-选择素和白介素-18在冠状动脉粥样斑块中相关表达

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第2期
页码:
220-221,227
栏目:
临床研究
出版日期:
2010-03-04

文章信息/Info

Title:
Correlative expression of P-selectin and IL-18 in human coronary atherosclerosis plaque
作者:
刘娟1; 魏俊香2; 陈丽琴3
内蒙古医学院:1.附属人民医院心内科，3.法医学系法医病理教研室，内蒙古 呼和浩特 010050；2.内蒙古妇幼保健医院内科，内蒙古 呼和浩特 010050
Author(s):
LIU Juan1;  WEI Jun-xiang2;  CHEN Li-qin3
1.Department of Cardiology, Affiliated Renming Hospital, 3.Department of Forensic Pathology, faculty of Forensic Medicine, Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia, China; 2.Department of Internal Medicine, Healthcare Hospital of Wome
关键词:
冠状动脉粥样硬化斑块; P-选择素; 白介素-18
Keywords:
coronary atherosclerosis plaques;  P-selectin;  interleukin-18
分类号:
R36;R543.5
DOI:
-
文献标识码:
A
摘要:
目的: 检测P-选择素（CD62P）和白介素-18（IL-18）在冠状动脉粥样硬化斑块中的表达水平，探讨CD62P和IL-18二者之间的相关性，为临床防治斑块形成和发展提供理论依据。方法: 选取65例尸检有粥样硬化的冠状动脉组织蜡块标本，采用免疫组化和图像分析技术检测冠脉中CD62P和IL-18的表达水平。结果: CD62P表达在冠状动脉血管内皮细胞膜上，表达水平增高时，粥样硬化斑块内巨噬细胞增多；IL-18主要表达在巨噬细胞胞浆中，CD62P表达增高时，IL-18表达也增高，二者表达具有相关性，并呈正相关关系(r=0.81，P<0.01)。结论: CD62P和IL-18在冠状动脉粥样硬化斑块中的表达具有相关性并呈正相关关系，提示二者可能在冠状动脉粥样斑块的形成和发展过程中是互相关联的炎症因子。
Abstract:
AIM: To evaluate the expression level and the relationship of P-selectin (CD62P) and interleukin-18 (IL-18) in human coronary atherosclerosis so as to provide theoretical evidence for clinical prevention and treatment of plaques. METHODS: Sixty five autopsy paraffin samples with coronary atherosclerosis were selected. The expression level of CD62P and IL-18 in the plaque of human coronary atherosclerosis was measured by immunohistochemical technique and image processing system. Data were analyzed statistically with SPSS v.13.0 software (SPSS, Chicago, IL). RESULTS: CD62P was expressed in vascular endothelial cell membrane. In coronary atherosclerosis plaques, the number of macrophages and the expression level of IL-18 changed consistently with the expression level of CD62P. A positive correlation was found between the expression of IL-18 and CD62P in the plaques (r=0.81, P<0.01). CONCLUSION: The expression levels of IL-18 and CD62P are correlated in human coronary atherosclerosis plaques.

参考文献/References

［1］ 郭爱桃，石怀银，韦立新,等. 人冠状动脉粥样硬化斑块内细胞成分与斑块稳定性关系［J］. 第四军医大学学报,2005, 26(22):2093-2096.

［2］ Ross R. Atherosclerosis an inflammatory disease［J］. N Engl J Med, 1999, 340(2):115-120.

［3］ Naruko T, Ueda M, Haze K, et al. Neutrophil infiltration of culprit lesions in acute coronary syndromes［J］. Circulation, 2002, 106(23):2894-2900.

［4］ Sakai A, Kume N, Nishi E, et al. P-selectin and vascular cell adhesion molecule-1 are focally expressed in aortas of hypercholesterolemic rabbits before intimal accumulation of macrophages and T lymphocytes［J］. Arterioscler Thromb Vasc Biol, 1997, 17(2):310-316.

［5］ Tenger C, Sundborger A, Jawien J, et al. IL-18 accelerate therosclerosis accompanied by elevation of IFN-gamma and CXCL16 expression ndependently of T cells［J］. Arterioscler Thromb Vasc Biol, 2005, 25(4):791-796.

［6］ Khew-goodall Y, Wadham C, Stein BN, et al. Stat-6 activation is essential for interleukin-4 induction of P-selectin transcription in human umbilical vein endothelial cells［J］. Arterioscler Thromb Vasc Biol, 1999, 19(6):1421-1429.

［7］ Mallat Z, Corbaz A, Scoazec A, et al. Interleukin-18/interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability［J］. Circ Res, 2001, 89(7):41-45.

备注/Memo

备注/Memo:
收稿日期：2008-12-29.通讯作者：陈丽琴，副教授，主要从事早期心肌梗死诊断方法研究Email：lqchenyx@163.com 作者简介：刘娟，副主任医师，硕士Email：remyliuj@126.com
更新日期/Last Update: 2010-03-05