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冠心病患者甲襞微循环、血液流变性、血脂及血糖的变化

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第2期
页码:
231-233
栏目:
临床研究
出版日期:
2010-03-04

文章信息/Info

Title:
Changes of nailfold microcirculation, hemodynamics and serum lipids and glucose in patients with coronary artery disease
作者:
李宝莉1; 杨杰2; 陈雅慧2; 钱盾3
延安大学医学院：1.药理学教研室，2.生理学教研室，3.2005级临床班，陕西 延安 716000
Author(s):
LI Bao-li1;  YANG Jie2;  CHEN Ya-hui2;  QIAN Dun3
1.Department of Pharmacology, 2.Department of Physiology, 3.Clinical Class, 2005 Grade, Medical College, Yan’an University, Yan’an 716000, Shaanxi, China
关键词:
冠状动脉疾病; 甲襞微循环; 血液流变性; 血脂; 血糖
Keywords:
coronary disease;  nailfold microcirculation;  hemodynamics;  serum lipid;  serum glucose
分类号:
R446.11
DOI:
-
文献标识码:
A
摘要:
目的: 通过观察冠心病(CHD)患者的甲襞微循环、血液流变学指标、血脂及血糖的变化，为及早诊断、治疗及预后判断提供依据。方法: 确诊为CHD的患者156例进行甲襞微循环、血液流变学、血脂及血糖等进行检测。结果: 与50例正常人相比较，CHD患者甲襞毛细血管数减少、交叉、畸形管襻增多，输入支变细、输出支和乳头下静脉丛扩张、血流速度减慢伴红细胞聚集；全血黏度、血浆黏度、红细胞压积、血沉、纤维蛋白原、血小板黏附性和聚集性增加；总胆固醇、三酰甘油、血糖增高，高密度脂蛋白胆固醇降低；并发有高血压病、糖尿病、高脂血症的CHD患者的甲襞微循环、血液流变性明显异常。结论: CHD患者的甲襞微循环、血液流变性、血脂、血糖明显异常；并发有高血压病、糖尿病、高血脂症的CHD患者甲襞微循环、血液流变性异常更为严重。
Abstract:
AIM: To observe the changes of nailfold microcirculation, hemodynamics, and serum lipid and glucose in patients with coronary artery disease (CAD) for early diagnosis, treatment and prognosis. METHODS: Nailfold microcirculation, hemodynamic and serum lipid and glucose changes were examined in 156 patients with CAD. RESULTS: Compared with those in the control (n=50), density of nailfold vasoloops, diameters of arterial limb of vasoloops and blood flow velocity decreased, whereas the intersection and deformity vasoloops, diameters of venous limb of vasoloops and subpapillary venous plexa density increased. Erythrocytes aggregated greatly and whole blood viscosity, plasma viscosity, ESR, fibrinogen, blood platelet adhesion and aggregation, total cholesterol, triglyceride and serum glucose levels were significantly higher, but the serum level of high-density lipoprotein cholesterol was significantly lower. Nailfold microcirculation and hemodynamics were evidently abnormal in patients with comorbid conditions such as hypertension, diabetes, or/and hyperlipidemia. CONCLUSION: Nailfold microcirculation, hemodynamics, and serum lipid and glucose in patients with CAD are clearly abnormal and the changes are more severe in CAD patients with comorbidiites such as hypertension, diabetes or/and hyperlipidemia.

参考文献/References

［1］ 田牛,单毅. 实用微循环学［M］. 北京: 军事科学出版社, 1989:177-189.

［2］ 贺信祥. 微循环——血液流变学基础与临床［M］. 香港: 香港科技联合出版社, 2000:340.

［3］ 安尼瓦尔·阿不力孜,杨坤河. 冠心病及其危险因素分析［J］. 新疆医科大学学报, 2005, 28(7):688-690.

［4］ 魏华江,李晓原,林红. 冠心病的血液流变性质改变［J］. 广东药学院学报, 1999, 15(2):113-115.

［5］ 施步程,陈清江. 冠心病某些新危险因素及其致病机理［J］. 解放军保健医学杂志, 2004, 6(3):186-188.

备注/Memo

备注/Memo:
收稿日期：2008-4-28.通讯作者：杨杰，副教授，主要从事神经生理学研究Email：jyang9369@163.com 作者简介：李宝莉，副教授，硕士Email：lbl_0812@163.com
更新日期/Last Update: 2010-03-05