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|本期目录/Table of Contents|

稳定型心绞痛患者对阿司匹林的反应性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第2期
页码:
237-239,243
栏目:
临床研究
出版日期:
2010-03-04

文章信息/Info

Title:
Clinical study on platelet reactivity in patients with stable angina
作者:
翟东东; 高炬; 王斌
北京大学航天临床医学院心内科，北京 100049
Author(s):
ZHAI Dong-dong;  GAO Ju;  WANG Bin
Department of Cardiology, College of Clinical Aerospace Medicine, Peking University, Beijing 100049, China
关键词:
血栓弹力图; 血小板反应性; 血栓前状态; C反应蛋白
Keywords:
thrombelastograph;  platelet reactivity;  prothrombotic status;  C-reactive protein
分类号:
R5414
DOI:
-
文献标识码:
A
摘要:
目的: 探讨在冠心病患者中，阿司匹林的个体差异及相关因素。方法: 稳定型心绞痛患者100例，服拜阿司匹林100 mg/d，7 d后测定血栓素B2（TXB2）、6-酮-前列腺素F1α（6-keto-PGF1α）、D-二聚体（D-D）、纤维蛋白原（FIB）、同型半胱氨酸（HCY）及C反应蛋白（CRP）水平，同时使用血栓弹力仪测定血小板的反应性，并根据反应性不同将患者分为四分位组（高反应性组和低反应性组），观察两组患者的临床特征。结果: 血小板反应性呈正态分布；高反应性的患者中女性（52% vs.28%，P<0.05）及糖尿病患者（64% vs.32%，P<0.05）的比例较高；血栓前状态标记物中TXB2［(102±17)ng/L vs.(74±17)ng/L,P<0.05］及CRP［(7.7±1.6)mg/L vs.(4.3±1.2)mg/L,P<0.05］在血小板高反应性的患者中高于低反应性组。结论: 冠心病患者血小板反应性存在个体差异。
Abstract:
AIM: To investigate the platelet reactivity in patients with coronary heart disease (CHD). METHODS: One hundred stable angina patients were given aspirin (100 mg, once daily) for 7 days. Thromboxane B2 (TXB2), 6-keto-prostaglandin F1α (6-6-keto-PGF1α), D-dimer (D-D), fibrinogen (FIB), homocysteine (HCY), and C-reactive protein (CRP) levels were then measured. The platelet reaction was measured by thrombelastograph (TEG). Patients were divided into high-platelet reaction groups (HPR) and low-platelet reaction groups (LPR). RESULTS: Platelet reactions were normally distributed. Females and patients with diabetes had higher platelet reactivity compared with males (52% vs. 28%, P<0.05) and patients without diabetes (64% vs. 32%, P<0.05). The prothrombotic status marker TXB2 ［(102±17) ng/L vs.(74±17) ng/L, P<0.05］ and CRP ［(7.7±1.6) mg/L vs.(4.3±1.2) mg/L, P<0.05］ were higher in HPR patients. CONCLUSION: Platelet reactivity in CHD patients has demonstrated some individual differences.

参考文献/References

［1］ Eikelboom JW, Hankey GJ. Aspirin resistance: a new independent predictor of vascular events?［J］. J Am Coll Cardiol, 2003, 41(6):966-968.

［2］ Tantry US, Bliden KP, Gurbel PA. Overestimation of platelet aspirin resistance detection by thrombelastograph platelet mapping and validation by conventional aggregometry using arachidonic acid stimulation［J］. J Am Coll Cardiol, 2005, 46(9):1705-1709.

［3］ Carroll RC, Craft RM, Chavez JJ, et al. A Thrombelastograph whole blood assay for clinical monitoring of NSAID-insensitive transcellular platelet activation by arachidonic acid［J］. J Lab Clin Med, 2005, 146(1):30-35.

［4］ Gum PA, Kottke-Marchant K, Welsh P, et al. A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease［J］. J Am Coll Cardiol, 2003, 41(6):961-965.

［5］ Chen WH, Lee PY, Ng W, et al. Aspirin resistance is associated with a high incidence of myonecrosis after nonurgent percutaneous coronary intervention despite clopidogrel pretreatment［J］. J Am Coll Cardiol, 2004, 43(6):1122-1126.

［6］ Ridker PM, Cook NR, Lee IM, et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women［J］. N Engl J Med, 2005, 352(13):1293-1304.

［7］ Watala C, Golanski J, Pluta J, et al. Reduced sensitivity of platelets from type 2 diabetic patients to acetylsalicylic acid (aspirin)-its relation to metabolic control［J］. Thromb Res, 2004, 113(2):101-113.

［8］ Tamminen M, Lassila R, Westerbacka J, et al. Obesity is associated with impaired platelet-inhibitory effect of acetylsalicylic acid in nondiabetic subjects［J］. Int J Obes Relat Metab Disord, 2003, 27(8):907-911.

［9］ Serebruany VL, Glassman AH, Malinin AI, et al. Platelet/endothelial biomarkers in depressed patients treated with the selective serotonin reuptake inhibitor sertraline after acute coronary events: the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy［J］. Circulation, 2003, 108(8): 939-944.

［10］Oltrona L, Ardissino D, Merlini PA, et al. C-reactive protein elevation and early outcome in patients with unstable angina pectoris［J］. Am J Cardiol, 1997, 80(8):1002-1006.

备注/Memo

备注/Memo:
收稿日期：2008-5-4.通讯作者：王斌，主任医师，主要从事冠心病及心律失常的介入治疗Binwang@yahoo.com.cn 作者简介：翟东东，硕士生Email:ddzhai@yahoo.com.cn
更新日期/Last Update: 2010-03-05