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|本期目录/Table of Contents|

芪丹通脉片治疗心绞痛的疗效分析

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第2期
页码:
249-250,254
栏目:
临床研究
出版日期:
2010-03-04

文章信息/Info

Title:
Effect of qidantongmai tablet in the treatment of angina pectoris
作者:
马静1; 王宗仁1; 孙静2; 姚菊峰1; 龙铟1; 行利1
第四军医大学西京医院：1.中医科，2.护理部,陕西 西安 710032
Author(s):
MA Jing1;  WANG Zong-ren1;  SUN Jing2;  YAO Ju-feng1;  LONG Yin1;  HANG Li1
1.Department of Traditional Chinese Medicine, 2.Department of Nursing, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China
关键词:
芪丹通脉片; 心绞痛; 疗效
Keywords:
qidantongmai tablet;  angina pectoris;  efficacy
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的: 观察芪丹通脉片(QDTMT )治疗冠心病心绞痛的临床疗效。方法: 将 205 例心绞痛患者，随机分为芪丹通脉片组和养心氏组；分别口服芪丹通脉片 4 片，养心氏片2 片，观察患者心绞痛发作次数、疼痛程度、持续时间、硝酸甘油服用量，以及胸闷、心悸、气短、倦怠乏力、自汗等中医症候和心电图的变化。结果: 芪丹通脉片组患者心绞痛总有效率为78.6%、显效率35.9%，养心氏组总有效率为71.5%、显效率30.3%，芪丹通脉片组中医证候显效率35.9 %、总有效率为 91.3 %，养心氏组显效率27.5 %，总有效率为86.4%，芪丹通脉片组心电图总有效率45.6%、显效率21.4%，养心氏组总有效率34.3%、显效率9.8%；两组心绞痛和中医证候总有效率相比无统计学差异，而芪丹通脉片组心电图总有效率显著高于养心氏组（P<0.05）。结论: 芪丹通脉片对心绞痛有较好的临床疗效。
Abstract:
AIM: To observe the effect of qidantongmai tablet (QDTMT) in the treatment of angina pectoris (AP). METHODS: Two hundred and five patients were randomized into QDTMT group and yangxinshi tablet (YXST) group. QDTMT (4 pills/day) and YXST (2 pills/day) were given, respectively, in the two groups for 28 days. The following changes were observed: frequency, persistence time and degree of pain of AP, dose of nitroglycerin used, chest distress, breath holding, arrhythmia, shortness of breath, lassitude and hypodynamia, spontaneous perspiration and electrocardiogram (ECG) changes. RESULTS: After 28 days, the total effective rate and excellence rate were 78.6% and 35.9% in QDTMT group, respectively, whereas those in YXST group were 71.6% and 30.4%, respectively. Total effective rate and excellence rate of traditional Chinese medicine symptoms were 91.3% and excellence rate was 35.9% in QDTMT group, whereas those were 86.4% and 27.5%, respectively, in the YXST group. ECG results showed that the total effective rate and the excellence rate were 45.6% and 21.4%, respectively, in the QDTMT group, whereas those were 34.3% and 9.8% in YXST group, respectively. No significant difference was found in the total effectiveness rate of AP and traditional Chinese medicine symptoms between QDTMT group and YXST group, but EKG results showed significant difference between the groups (P<0.05). CONCLUSION: QDTMT is effective in treating AP.

参考文献/References

［1］ 陶寿淇. 我国心血管病及其危险因素近年演变趋势［J］. 中华心血管病杂志, 1999, 8(27):246-247.

［2］ 马静,王宗仁,马世平,等. 芪丹通脉片对犬心肌耗氧量的影响［J］. 第四军医大学学报, 2003, 24(5):403-405.

［3］ 马静,王宗仁,马世平,等. 降粘抗栓片对犬冠状动脉血流量及阻力的影响［J］. 西安医科大学学报, 2001, 22(3):221-223.

［4］ 鲍臻,夏天,王宗仁,等. 芪丹通脉片对急性心肌缺血犬血液流变学及生化指标的影响［J］. 心脏杂志, 2001, 13(2):125-127.

［5］ 康建华，张跃义，赵连友. 比较复方丹参滴丸与丹参片治疗冠心病心绞痛的疗效［J］. 心脏杂志, 2002, 14(4):321-322.

［6］ 张宁宁,尹承娥, 吕方方. 气滞血瘀、气虚血瘀心绞痛患者心率变异性与心肌缺血指数相关性探讨［J］ . 山东中医药大学学报, 2003, 27(2):123-124.

备注/Memo

备注/Memo:
收稿日期：2008-12-15.基金项目：全军医药卫生科研基金项目资助（2000B07）；陕西省科技攻关课题［2001K11-G7(5)］ 通讯作者：王宗仁， 教授，主要从事心血管病中西医结合诊断治疗研究Email:zongren@fmmu.edu.cn 作者简介：马静，副主任医师，博士Email：jingma@fmmu.edu.cn
更新日期/Last Update: 2010-03-05