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|本期目录/Table of Contents|

磁性微球聚乳酸复合材料生物相容性研究

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第3期
页码:
361-364
栏目:
基础研究
出版日期:
2010-04-06

文章信息/Info

Title:
Effects on biocompatibility of composite materials of magnetic microsphere poly(L-lactide)
作者:
张晶1; 于德梅1; 吕安林2 ; 邢玉洁2
1.西安交通大学理学院应用化学专业，陕西 西安 710048；2.第四军医大学西京医院心血管内科，陕西 西安 710032
Author(s):
ZHANG Jing1;  YU De-mei1;  LV An-lin2;  XING Yu-jie2
1.Department of Applied Chemistry, School of Science, Xi'an Jiaotong University, Xi’an 710049; Shanxi, China; 2.Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shanxi, China
关键词:
磁性材料; 可降解; 内皮细胞; 相容性; 雷帕霉素
Keywords:
magnetic materials;  vascular endothelial cells;  biodegradable;  compatibility;  rapamycin
分类号:
R543
DOI:
-
文献标识码:
A
摘要:
目的: 探讨自制的新型磁性微球聚乳酸复合材料及载药雷帕霉素磁性微球聚乳酸复合材料对血管内皮细胞增殖的影响。方法: 将不同含量的磁性聚合物微球聚乳酸复合材料和磁性聚合物微球的载药雷帕霉素聚乳酸磁性复合材料放置于培养的血管内皮细胞溶液中，标准条件下共培养4 d后，四噻唑蓝比色法测定细胞数量，倒置显微镜下观察内皮细胞的增殖情况。结果: 培养1、2、3、4 d的磁性微球聚乳酸复合材料不同浓度组对血管内皮细胞生长均有明显的促进作用（P<0.05）。雷帕霉素是抑制内皮细胞生长，但是载药的磁性微球聚乳酸复合材料各浓度组内皮细胞的数量显著多于单纯药物对照组（P<0.05），磁性复合材料显著的减弱了雷帕霉素对内皮细胞的抑制作用。结论: 磁性微球复合材料对血管内皮细胞具有促进生长的作用。
Abstract:
AIM: To investigate the effects of new magnetic composite materials regarding magnetic microsphere (MMS) and poly(L-lactide) (PLLA) on proliferation of vascular endothelial cells (VEC). METHODS: Different contents of MMS/PLLA and rapamycin/MMS/PLLA were added to the cell culture medium and kept under standard conditions for 4 days. MTT was used to determine the amount of VEC proliferation. RESULTS: The amount of the VEC proliferation was significantly higher than in the control group (P<0.05). There was a higher proliferation of rapamycin/MMS/PLLA than rapamycin/PLLA (P<0.05). Magnetic composite materials significantly weakened the inhibitory effect of rapamycin on endothelial cells. CONCLUSION: Magnetic composites may promote the growth of vascular endothelial cells.

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备注/Memo

备注/Memo:
收稿日期：2009-06-16.通讯作者：吕安林，主任医师，主要从事心血管疾病的基础与临床研究Email:lvanlin@fmmu.edu.cn 作者简介：张晶，博士生Email:jz930@163.com
更新日期/Last Update: 2010-04-09