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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2010年第3期

页码:

386-389

栏目:

临床研究

出版日期:

2010-04-06

文章信息/Info

Title:

Plasma brain natriuretic peptide in predicting in-stent restenosis

作者:

肖春晖¹; 杨向军¹; 张邢炜²; 陈玉林²; 励伟芬²; 王利波²; 薛树仁²

1．苏州大学医学院附属第一医院心内科，江苏 苏州 215006；2．杭州师范大学附属医院，浙江 杭州 310012

Author(s):

XIAO Chun-hui¹;  YANG Xiang-jun¹;  ZHANG Xing-wei²;  CHEN Yu-lin²;  LI Wei-fen²;  WANG Li-bo²;  XUE Shu-ren²

1.Department of Cardiology, First Affiliated Hospital of Medical School, Suzhou University, Suzhou 215006, Jiangsu, China; 2.Department of Cardiology, Affliated Hospital of Hangzhou Normal University, Second Hangzhou City Hospital, Hangzhou 310002, Zhejiang, China

关键词:

脑钠尿肽;  冠状动脉支架植入术; 支架内再狭窄

Keywords:

Brain natriuretic peptide;  percutaneous coronary stent implantation;  in-stent restenosis

分类号:

R541.4

DOI:

-

文献标识码:

A

摘要:

目的: 探讨冠心病患者血浆脑钠尿肽(BNP)水平与冠状动脉支架内再狭窄的关系。方法: 选择317例接受冠状动脉支架植入术（PCI）以及术后1年内再次接受冠状动脉造影(CAG)检查的患者，分为再狭窄和无再狭窄组，分别在PCI术前、出院前和复查CAG前测定血浆BNP水平，两组患者分别比较相应的BNP水平。结果: 再狭窄组PCI术前、出院前及复查CAG前的BNP水平与无再狭窄组分别进行比较，差异有统计学意义（P<0.05），多因素logistic回归分析结果，血浆BNP水平是预测再狭窄的独立危险因子（均P<0.01）。结论: 血浆BNP水平与PCI术后再狭窄密切相关，有可能作为再狭窄的有用预测指标。

Abstract:

AIM: To study the relationship between brain natriuretic peptide (BNP) and intracoronary in-stent restenosis. METHODS: A total of 317 patients with acute coronary syndrome (ACS) or stable angina pectoris (SAP) successfully treated with percutaneous coronary stent implantation (PCI) were examined with a follow-up coronary angiography. Study subjects were divided into in-stent restenosis (ISR) group and no ISR group. Blood samples for BNP were obtained before PCI, at hospital discharge and during angiographic follow-up. RESULTS: Patients with restenosis had significantly higher plasma BNP levels than their counterparts without restenosis (P<0.05). Multivariate logistic regression analysis revealed that high plasma BNP level was an independent predictor of ISR. CONCLUSION: Plasma BNP level can be used as a predictive factor for restenosis after PCI.

参考文献/References

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［2］ Sabatine MS, Morrow DA, de Lemos JA, et al. Acute changes in circulating natriuretic peptide levels in relatin to myocardial ischemia［J］. J Am Coll Cardiol, 2004, 44(10):1988-1995.

［3］Goetze JP, Christoffersen C, Perko M, et al. Increaseed cardiac BNP expression associated with myocardial ischemia［J］. FASEB J, 2003, 17(9):1105-1107.

［4］Miller WL, Hartman KA, Burritt MF, et al. Serial biomarker measurements in ambulatory patients with chronic heart failure: the importance of change over time［J］. Circulation, 2007, 116(3):249-257.

［5］ Richards M, Nicholls MG, Espiner EA, et al. Comparison of B-type natriuretic peptides for assessment of cardiac function and prognosis in stable ischemic heart disease［J］. J Am Coll Cardiol, 2006, 47(1):52-60.

［6］ Kalra PR, Gomma A, Daly C, et al. Relation in plasma concentrations of N terminal pro B type natriuretic peptide following percutaneous coronary intervention［J］. Heart, 2004, 90(11):1334-1335.

［7］Hong SN, Ahn Y, Yoon NS, et al. Usefulness of serum N-terminal pro brain natriuretic peptide to predict in-stent restenosis in patients with preserved left ventricular function and normal troponin I levels［J］. Am J Cardiol, 2007, 99(8):1051-1054.

［8］Kastrati A, Schomig A, Elezi S, et al. Predictive factors of restenosis after coronary stent placement［J］. J Am Coll Cardiol, 1997, 30(6):1428-1436.

备注/Memo

备注/Memo:

收稿日期：2009-04-02.作者简介：肖春晖，主治医师，博士生 Email:feifei19701021@yahoo.com

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更新日期/Last Update: 2010-04-09