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盐酸曲美他嗪对急性病毒性心肌炎的心肌保护作用观察

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第3期
页码:
406-407，411
栏目:
临床研究
出版日期:
2010-04-06

文章信息/Info

Title:
Study on the protective effects of trimetazidine dihydrochloride on acute viral myocarditis
作者:
余浩1; 李姣2
1.湖北省新华医院心内科，湖北 武汉 430015；2.武汉市汉口医院内科，湖北 武汉 430012
Author(s):
YU Hao1;  LI Jiao2
1.Department of Cardiology, Hubei Xin Hua Hospital, Wuhan 430015, Hubei, China; 2.Department of Internal Medicine, Hankou Hospital of Wuhan, Wuhan 430012, Hubei, China
关键词:
盐酸曲美他嗪; 心肌炎; 病毒性
Keywords:
trimetazidine dihydrochloride;  viral myocarditis
分类号:
R542.21
DOI:
-
文献标识码:
A
摘要:
目的: 观察盐酸曲美他嗪对急性病毒性心肌炎的心肌保护作用。方法: 选择符合成人急性病毒性心肌炎诊断标准的患者86例，随机分为治疗组（40例）和对照组（46例）。两组患者均卧床休息,应用抗生素、激素综合治疗，而治疗组在综合治疗基础上加用盐酸曲美他嗪片口服治疗。治疗前后采患者静脉血检测CK、CK-MB、肌钙蛋白I、血沉(ESR)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子（TNF-α）等指标。结果: 盐酸曲美他嗪治疗组治疗后CK、CK-MB、肌钙蛋白I、hs-CRP及TNF-α等指标水平均比对照组低（P<0.05）；仅ESR结果无显著差异。结论: 盐酸曲美他嗪对急性病毒性心肌炎的心肌有很好的保护作用。
Abstract:
AIM: To explore the protective effect of trimetazidine dihydrochloride on acute viral myocarditis. METHODS: Eighty six patients with acute viral myocarditis were randomly divided into trimetazidine dihydrochloride metabolic drug treatment group (n=40) and usual routine treatment group (n=46). Patients in both groups were bedridden and were treated with antibiotics and hormones. Metabolic drug treatment group was administered trimetazidine dihydrochloride in addition to the synthetic treatment. Before and after treatment, venous blood was collected and tested including CK-MB, cTnI, ESR, hs-CRP and TNF-α. RESULTS: Levels of CK-MB, cTnI, hs-CRP and TNF-α of trimetazidine dihydrochloride treatment group were lower than levels of the routine treatment group (P<0.05), but no significant difference was observed between the ESR levels of the two groups. CONCLUSIONS: Trimetazidine dihydrochloride has demonstrated a protective effect on acute viral myocarditis.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2009-01-09.作者简介：余浩，主治医师，硕士Email:banana820124@21cn.com
更新日期/Last Update: 2010-04-09