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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2010年第4期

页码:

579-580,591

栏目:

临床研究

出版日期:

2010-06-10

文章信息/Info

Title:

Effect of brain natriuretic peptides in treatment of patients with severe congestive heart failure

作者:

翟红霞; 殷亚昕; 李良; 张津津; 陈海威; 刘润梅; 夏云峰

解放军总医院第一附属医院干一科，北京 100037

Author(s):

ZHAI Hong-xia;  YIN Ya-xin;  LI liang;  ZHANG Jin-jin;  CHEN Hai-wei;  LIU Run-mei;  XIA Yun-feng

VIP Ward, First Affiliated Hospital, PLA General Hospital, Beijing 100037, China

关键词:

心力衰竭; 充血性; 脑钠尿肽; 重组; 疗效

Keywords:

congestive heart failure;  recombinant;  brain natriuretic peptide;  therapeutic response

分类号:

R541.61

DOI:

-

文献标识码:

A

摘要:

目的: 观察脑钠尿肽（BNP）治疗重症充血性心力衰竭（CHF）患者的疗效。方法: 纽约心脏学会心功能分级IV级的重症CHF患者44例，在基础抗心衰治疗基础上，应用重组人BNP（rh-BNP）进行治疗，观察患者心率、血压、出入量、中心静脉压、肾功能、血浆BNP水平、左心室舒张末径（LVEDD）和左心室射血分数（LVEF）的变化，观察BNP的疗效。结果: 44例患者中40例患者心衰症状明显改善，总有效率91%。治疗后患者尿量明显增加，心率、中心静脉压、血浆BNP水平均较治疗前明显下降，LVEDD缩小，LVEF较治疗前升高，治疗前后血压和肾功能无明显改变。结论: 外源性rh-BNP的应用可以明显改善患者心衰症状。治疗重症CHF安全，可靠。

Abstract:

AIM: To observe the therapeutic effect of brain natriuretic peptide (BNP) in the treatment of severe congestive heart failure. METHODS: Recombinant BNP was used based on basic anti-heart failure treatment in 44 patients with severe congestive heart failure and heart function classified as New York Heart Association (NYHA) IV. Changes in heart rate, blood pressure, central venous pressure, renal function, plasma BNP level, left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) after treatment were observed to evaluate BNP effect. RESULTS: After treatment, clinical symptoms in 40/44 cases were alleviated and the total response rate was 90.9%. Diuresis increased significantly and, at the same time, heart rate, central venous pressure and plasma BNP level decreased markedly. LVEDD was reduced and LVEF was improved. No obvious changes were observed in blood pressure and renal function. CONCLUSION: Recombinant BNP markedly alleviated the clinical symptoms of heart failure. It is a safe and effective treatment for severe congestive heart failure.

参考文献/References

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备注/Memo

备注/Memo:

收稿日期：2009-04-16.作者简介:翟红霞，副主任医师，硕士生Email:dr_hxzhai@sina.com

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更新日期/Last Update: 2010-05-20