阿托伐他汀对大鼠动脉粥样硬化不稳定斑块内新生血管的影响
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2010年第5期
- 页码:
- 654-657
- 栏目:
- 基础研究
- 出版日期:
- 2010-06-22
文章信息/Info
- Title:
- Effect of atorvastatin on atherosclerotic neovascularization in atherosclerotic rats
- Author(s):
- ZHANG Yan; XIA Hao; NIE Xiao-lei
- Cardiovascular Research Institute, Renmin Hospital, Wuhan University, Wuhan University, Wuhan 430060, Hubei, China
- Keywords:
- atherosclerosis; neovascularization; atorvastatin; vulnerable plaque
- 分类号:
- R541.4
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的: 研究阿托伐他汀药物对大鼠动脉粥样硬化斑块内血管生成的影响及可能机制，观察粥样斑块内血管生成与斑块稳定性的关系。方法: 将36只大鼠随机分为正常组,高脂组和阿托伐他汀组。14周后处死大鼠，取血测定血脂及C反应蛋白，观察主动脉病理学变化；测量斑块面积及内膜中膜面积比（I/M）；微血管密度（MVD）测定，免疫组化观察并分析斑块内Ⅷ因子的表达。结果: ①高脂组和阿托伐他汀组血清脂质水平高于正常组（P<0.05）,而二者之间无明显差异性;②高脂组和阿托伐他汀组I/M较正常组明显增多（P<0.05）,而阿托伐他汀组I/M较高脂组明显减少（P<0.05）；③阿托伐他汀和高脂组斑块内MVD及Ⅷ因子阳性率均明显均高于正常组，而阿托伐他汀组MVD及Ⅷ因子阳性率均低于高脂组（P<0.05）;结论: 新生血管多发生在不稳定斑块内，斑块内血管生成是增加斑块不稳定性的又一因素,阿托伐他汀可以减少斑块内血管生成，达到稳定斑块的作用。
- Abstract:
- AIM: To investigate the effect of atorvastatin on the initiation and progression of atherosclerotic neovascularization and plaque stability. METHODS: Thirty-six Wistar rats were randomly divided into normal high lipid group (group A), atorvastatin treatment group (group B) and control group (group C). Animal models of atherosclerosis were established and serum cholesterol and Hs-CRP levels in plasma, as well as intimal area and middle area (I/M) and MVD, were measured in each group. The expression of VIII in group A and group B and the atherosclerosis plaques were detected and measured by immunohistochemistry. RESULTS: Serum cholesterol levels were similar in group A and group B and significantly higher than in group C (P<0.05). Compared with group C, Hs-CRP in group A and group B increased significantly (P<0.05) and the level of Hs-CRP in group B was markedly lower than in group A (P<0.05). The ratio of I/M and the MVD in atherosclerotic plaques in group B were lower than in group A (P<0.05). Compared with group A, the expression of VIII in atherosclerotic plaques in group B decreased significantly (P<0.05). CONCLUSION: Neovascularization aggravates plaque instability and atorvastatin inhibits neovascularization and plaque growth, thus improving plaque stabilization.
参考文献/References
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备注/Memo
- 备注/Memo:
- 收稿日期：2009-07-01.通讯作者：夏豪，主任医师，主要从事心血管病特别是冠心病的防治研究Email:xiahao1966@163.com 作者简介：张燕,硕士生Email:libo303@yahoo.cn
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