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|本期目录/Table of Contents|

牙龈卟啉单胞菌对心血管内皮细胞黏附和入侵的研究

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第5期
页码:
692-694
栏目:
基础研究
出版日期:
2010-06-22

文章信息/Info

Title:
Invasion of porphyromonas gingivalis to human coronary artery endothelial cells
作者:
宋红马秦吕昕赵蕊妮
第四军医大学口腔医学院综合急诊科,陕西 西安 710032
Author(s):
SONG Hong MA Qin LV Xin ZHAO Rui-ni
Department of General Dentistry, School of Stomatoloy, Fourth Military Medical University, Xi’an 710032, Shaanxi, China
关键词:
牙龈卟啉单胞菌牙周炎心血管疾病
Keywords:
porphyromonas gingivalis periodontitis coronary heart disease
分类号:
R329.25
DOI:
-
文献标识码:
A
摘要:
目的: 牙龈卟啉单胞菌(Porphyromonas gingivalis,P.g)作为牙周炎致病菌,同时也能引起心血管系统的疾病。在本研究中,比较4种P.g对人牙龈上皮细胞,人心血管内皮细胞,和人脐静脉内皮细胞的黏附和入侵。探讨P.g对人牙龈上皮细胞和心血管内皮细胞的黏附和入侵能力。方法: 通过抗菌素保护实验检测细菌对各种细胞的黏附和入侵能力。结果: 各种细菌的黏附和入侵能力是不同的,相同细菌对不同细胞的黏附和入侵也各有不同,P.g对人牙龈上皮细胞,人心血管内皮细胞的黏附和入侵明显高于对人脐静脉内皮细胞的黏附和入侵。结论: P.g菌株对牙龈上皮细胞和人心血管内皮细胞有着相似的黏附和入侵能力。
Abstract:
AIM: To explore the invasion of porphyromonas gingivalis (P.g), a periodontal pathogen, in the pathogenesis of coronary heart disease. METHODS: Four different strains of P.g were tested for adhesion and invasion of human gingival epithelial cells (HGEC), human umbilical vein endothelial cells (HUVEC) and human coronary artery endothelial cells (HCAEC). The strains were tested for the ability to attach to and invade HGEC, HUVEC and HCAEC using a standard antibiotic protection assay. RESULTS: Data indicated that the invasion efficiency of P.g was different among the different strains. The same strain showed a different ability to adhere to and invade different types of cells. The efficiency of P.g adhesion and invasion of HGEC and HCAEC was higher than HUVEC. CONCLUSION: P.g strains have a stronger ability to adhere to and invade both HGEC and HCAEC.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期:2009-08-13.作者简介:宋红,副主任医师Email:songhong@fmmu.edu.cn
更新日期/Last Update: 2010-06-22