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急性冠脉综合征单核细胞中PPARδ的表达及与血清IL-6、IL-10水平的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第5期
页码:
716-718，738
栏目:
临床研究
出版日期:
2010-06-22

文章信息/Info

Title:
Correlation between levels of peroxisome proliferator-activated receptors δ expression in peripheral blood monocyte and serum levels of IL-6 and IL-10 in patients with acute coronary syndrome
作者:
杨大春; 马双陶; 杨永健; 谭艳; 李德; 唐兵; 速晓华
成都军区总医院心血管内科，四川 成都 610083
Author(s):
YANG Da-chun;  MA Shuang-tao;  YANG Yong-jian;  TAN Yan;  Li De;  TANG Bing;  SU Xiao-hua
Department of Cardiology, General Hospital, Chengdu Military Area Command, Chengdu 610083, Sichuan, China
关键词:
急性冠脉综合征; 过氧化物酶增殖激活受体δ; IL-6; IL-10
Keywords:
coronary artery disease;  monocytes;  gene expression;  adhesion molecule
分类号:
R543.3
DOI:
-
文献标识码:
A
摘要:
目的: 探讨急性冠脉综合征(ACS)患者单核细胞中过氧化物酶体增殖激活受体δ(PPARδ)的表达水平与血清IL-6和IL -10水平的相关性。方法： 分离55例ACS患者和47例健康对照者的外周血单核细胞，应用RT-PCR法检测PPARδ的表达；应用ELISA法检测白血清IL-6和IL-10的水平。结果： ACS患者外周血单核细胞中PPARδ的表达水平显著低于健康对照组(P<0.01)；血清IL-6水平显著高于健康对照组(P<0.01)；而血清IL-10的水平显著低于健康对照组(P<0.01)。PPARδ的表达水平与血清IL-6的水平呈负相关(r=-0.413，P<0.05)，与血清IL-10的水平呈正相关(r=0.601，P<0.05)。结论： PPARδ可能在ACS的发病中具有重要作用。
Abstract:
AIM: To evaluate the correlation between the levels of peroxisome proliferator-activated receptors δ (PPARδ) expression in peripheral blood monocytes and the serum levels of interleukin-6 (IL-6) and interleukin-10 (IL-10) in patients with acute coronary syndrome (ACS). METHODS: Peripheral blood monocytes were collected from 55 patients with ACS and 47 healthy controls. The PPARδ expression was detected by RT-PCR and the serum levels of IL-6 and IL-10 were measured by ELISA assay. RESULTS: The PPARδ expression levels were markedly reduced in peripheral blood monocytes from patients with ACS compared with those from healthy controls (P<0.01). The serum IL-6 level was significant higher while the IL-10 level was obvious lower in patients with ACS compared with those in controls (both P<0.01). The PPARδ expression level was negatively correlated to the IL-6 level (r=-0.413, P<0.05) and positively correlated to the IL-10 level (r=0.601, P<0.05). CONCLUSION: PPARδ may play a critical role in the pathogenesis of ACS.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2009-12-27.作者简介：杨大春，主治医师，博士Email:yangdc71@126.com
更新日期/Last Update: 2010-06-22