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|本期目录/Table of Contents|

α1A/C-肾上腺素受体对心肌的保护作用

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第5期
页码:
774-776
栏目:
综述
出版日期:
2010-06-22

文章信息/Info

Title:
-
作者:
牟杨1综述李刚1张灿晶2审校
1.重庆医科大学附属第一医院老年科心血管病组,重庆 400016;2.重庆市西郊医院功能检查科,重庆 400050
Author(s):
-
关键词:
肾上腺素受体α1A/C受体心肌细胞
Keywords:
-
分类号:
Q577
DOI:
-
文献标识码:
A
摘要:
心肌细胞上存在α1A/C、α1B、α1D, β1、β2、β3等肾上腺素受体(AR)亚型,均属于G蛋白偶联受体超家族。一般认为,β1等AR持续兴奋对心肌是有害的;而近来的研究发现,α1A/C-AR在压力超负荷和心肌梗死等病理情况下,可能对心肌具有保护作用。本文综述了α1A/C-AR对心脏功能的调节作用。
Abstract:
-

参考文献/References

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[13]孙梅芹,闫翔,王建,等. 不同肾上腺素能受体阻滞剂对超压力负荷大鼠左室重构的影响[J]. 心脏杂志, 2008, 20(5):537-540.

[14]OConnell TD, Swigart PM, Rodrigo MC, et al. Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload[J]. J Clin Invest, 2006, 116(4):1005-1015.

备注/Memo

备注/Memo:
收稿日期:2009-09-03.基金项目:重庆市科委自然科学基金计划资助项目[渝科发计 字(2007)25号CSTC,2007BB5276]; 重庆市卫生局医学科学技术研究项目[渝卫教2004(53)04-2-154] 通讯作者:李刚,副教授,主要从事冠心病及其并发症的发病机制研究Email:harborli@126.com 作者简介:牟杨,硕士生Email:muyang427@163.com
更新日期/Last Update: 2010-06-22