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|本期目录/Table of Contents|

低声压级水平次声对心肌梗死大鼠心肌纤维化的影响及机制研究

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第6期
页码:
852-855
栏目:
基础研究
出版日期:
2010-08-23

文章信息/Info

Title:
Effects of low-decibel infrasound on cardiac fibrosis of rats with acute myocardial infarction and underlying mechanism
作者:
吴敬国1梁艳冰1唐皓1裴兆辉2庄志强3马虹2马中富1
中山大学附属第一医院:1.普内科,2.心内科,广东 广州 510080;3.中山大学附属第二医院康复科,广东 广州 510120
Author(s):
WU Jing-guo1 LIANG Yan-bing1 TANG Hao1 PEI Zhao-hui2 ZHUANG Zhi-qiang3 MA Hong2 MA Zhong-fu1
1.Department of Internal Medicine, 2.Department of Cardiology, First Affiliated Hospital, SUN YAT-Sen University, Guangzhou 510080, Guangdong, China; 3.Department of Physical Therapy and Rehabilitation, Second Affiliated Hospital, SUN YAT-Sen University, Guangzhou 510120, Guangdong, China
关键词:
次声大鼠心肌纤维化心肌梗死
Keywords:
infrasound rat cardiac fibrosis myocardial infarction
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的: 观察次声对心肌梗死后大鼠心肌纤维化的影响及相关机制研究。方法: 将30只SD大鼠随机分为3组,即假手术组、心肌梗死组及次声治疗组,每组10只。采用低声压级水平次声对心肌梗死大鼠治疗1周(2次/d,0.5 h/次), 观察心肌胶原和血浆NO和血管紧张素-Ⅱ(AngⅡ)及大鼠心功能的变化。结果: 与心肌梗死组大鼠比较(未治疗组),次声治疗组大鼠心肌胶原表达明显减少,血浆NO含量显著增加(P<0.01),血浆AngⅡ含量显著降低(P<0.01),心功能明显改善(P<0.01)。结论: 低声压级水平次声治疗能够明显减轻心肌梗死后大鼠心肌纤维化,其作用可能与血浆NO及AngⅡ含量变化有关。
Abstract:
AIM: To observe the changes of cardiac fibrosis and its underlying mechanism after acute myocardial infarction in rats. METHODS: Thirty male Sprague Dawley rats were randomized to control group, infarction group and infrasound treatment group (10 rats/group). Rats in the infrasound treatment group were treated with infrasound for 7 days, 0.5 h, twice/day. Collagen expression of rat myocardium and contents of NO and Ang-II in rat plasma and rat heart function were observed. RESULTS: Compared with those in the infarction group, the collagen expression of rat myocardium increased in the infrasound treatment group (P<0.01), the contents of NO in rat plasma significantly decreased (P<0.01), the contents of ET-1 in rat plasma significantly increased (P<0.01), and heart function was significantly improved. CONCLUSION: Infrasound treatment significantly assuages the cardiac fibrosis of rats after myocardial infarction, which may be relative with the changes of NO and Ang-II.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期:2009-08-21.基金项目:中国博士后科学基金资助(20081266);国家自然科学基金项目资助(30870579) 通讯作者:马中富,主任医师,主要从事内科基础及临床研究Email:ma_zf@pom.com 共同通讯作者:裴兆辉,副教授,主要从事次声生物学效应研究Email:leak123@126.com 作者简介:吴敬国,医师,博士Email:leak123@sina.com.cn
更新日期/Last Update: 2010-08-22