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Title:: Establishment of a canine model of fat embolism induced no/slow flow of coronary artery

作者:: 潘侨; 程何祥; 郭文怡; 李飞; 李虎; 程康; 张荣庆; 第四军医大学第一附属医院心血管内科,陕西西安 710032

Author(s):: PAN Qiao; CHENG He-xiang; GUO Wen-yi; LI Fei; LI Hu; CHENG Kang; ZHANG Rong-qing; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China

关键词:: 脂肪栓子; 慢/无血流现象; 冠脉造影; TIMI血流计帧法

Keywords:: fat embolus; slow/no flow phenomenon; coronary angiography; TIMI frame count

分类号:: R543

DOI:: -

文献标识码:: A

摘要:: 目的：建立犬冠状动脉脂肪栓塞动物模型，为介入性无复流发生过程中脂肪栓塞的作用提供理论依据。方法: 杂种犬20只，施行左室造影及冠状动脉造影，记录血流动力学参数，脂肪栓子注入后，造成犬优势动脉无复流，观察造影结果。同步监测体表心电图，并监测其后组织学及超微结构的改变。结果: 建模中共有17只犬成活，其中15只犬达到冠状动脉造影无复流动物模型的标准，即(TIMI)血流≤Ⅱ级，校正的TIMI血流记帧法(CTFC)≥36.2帧，建模成功率75%。慢/无血流模型建立成功后，心率增快，血压下降，左室收缩末压显著降低(P<0.05)。实验过程中，体表心电图出现急性心肌损伤及再灌注的心电图衍变规律。结论: 选择性冠状动脉内注入脂肪栓子建立的慢/无血流犬模型是成功的。

Abstract:: AIM: To establish a canine model of fat embolism-induced no/slow flow of coronary artery for the study of the involvement of fat embolism in the pathogenesis of interventional slow/no flow. METHODS: Twenty hybrid dogs were subjected to left ventricular imaging and coronary angiography as well as hemodynamic parameter measurement at baseline. Intracoronary infusion of fat emboli was accomplished to produce slow/no flow of the dominant coronary artery, which was confirmed by coronary angiography. Electrocardiogram (ECG) and vital signs were recorded throughout the procedures. RESULTS: Seventeen dogs survived the procedure and 15 met the standard of coronary angiography for slow/no flow in animal models, i.e., TIMI flow grade ≤II and corrected TIMI frame count (CTFC)≥36.2. Overall success rate was 75%. After the establishment of slow/no flow model, the heart rate increased rapidly, blood pressure decreased and left ventricular systolic pressure significantly decreased (P<0.05). During the process, ECG showed similar evolvement as that of acute myocardial injury and reperfusion. CONCLUSION: Intracoronary injection of ultraselected fat is a good way to produce canine models of slow/no flow during percutaneous coronary intervention.

参考文献/References

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犬冠状动脉脂肪栓塞引起慢/无血流模型的建立

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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