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|本期目录/Table of Contents|

冠心病稳定型心绞痛患者抑郁与血清白介素-1β水平相关

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第6期
页码:
897-900
栏目:
临床研究
出版日期:
2010-08-23

文章信息/Info

Title:
Study on serum interleukin-1β level in depressed patients with coronary heart disease
作者:
帕丽达·阿布来提1库木斯2古丽扎尔·买买提明1
新疆医科大学第一附属医院:1.干部心血管二科;2.心身科,新疆 乌鲁木齐 830054
Author(s):
PA Li-da1 KU Musi2 GU Li Zaer3
1.Second Department of Cardiology, 2.Department of Psychosomatics, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang, China
关键词:
冠状动脉疾病抑郁白细胞介素-1β
Keywords:
coronary disease depression interleukin-1β
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的: 研究抑郁对冠心病稳定型心绞痛患者血清白介素-1β(IL-1β)水平的影响。方法: 收集2007年7月~12月住院治疗年龄≥50岁的冠心病稳定型心绞痛患者86例。根据ZUNG抑郁自评量表(SDS)评定标准分组,即冠心病伴抑郁患者62例,冠心病不伴抑郁患者24例,对两组患者的临床特征,血脂、血糖及IL-1β检测结果进行对比分析。结果: 两组患者在年龄、性别构成、吸烟、饮酒、受教育程度、并发高血压病、糖尿病等之间的差异无统计学意义。冠心病伴抑郁组IL-1β水平显著高于冠心病不伴抑郁组(P<0.05)。SDS问卷积分与IL-1β呈正相关(r=0.30,P<0.01)。同时按轻、中、重程度与IL-1β相关分析也呈正相关(r=0.35,P<0.05)。两组患者血脂水平无显著性差异,且与IL-1β之间没有相关性。结论: 冠心病稳定型心绞痛患者抑郁与血清IL-1β水平相关。
Abstract:
AIM: To investigate the influence of depression on the serum interleukin-1β level of patients with coronary heart disease (CAD) with stable angina pectoris (SAP). METHODS: Eighty-six patients (age≥50 years) with CAD with SAP admitted to our department from August 2007 to December 2007 were divided into two groups by ZHUG questionnaire (SDS) scores: Group A (patients with depression, n=62) and Group B (patients without depression, n=24). We analyzed the clinical data, serum lipids, blood glucose and interleukin-1β level of all patients in the two groups. RESULTS: No significant difference was found in age, gender, smoking, alcohol use, educational level, complications of hypertension, and complications of diabetes. The level of interleukin-1β in patients with CHD accompanied by depression was significantly higher than in patients with CHD without depression (P<0.05). Correlation analysis results showed that the SDS score was positively related to the level of interleukin-1β (r=0.35, P<0.05). No significant difference was observed in lipid level between groups and no correlation was found with interleukin-1β level. CONCLUSION: The level of interleukin-1β was positively related in CHD patients with SAP accompanied by depression.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期:2009-06-12.基金项目:新疆维吾尔自治区自然科学基金项目(200721113) 通讯作者:古丽扎尔·买买提明,主任医师,主要从事心血管疾病与心理行为的相关研究 Email:parida226@126.com 作者简介:帕丽达·阿布来提,住院医师,硕士Email:parida226@126.com
更新日期/Last Update: 2010-08-22