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|本期目录/Table of Contents|

PAPP-A基因IVS6+95多态性与不稳定型心绞痛的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第6期
页码:
905-908
栏目:
临床研究
出版日期:
2010-08-23

文章信息/Info

Title:
Relationship between pregnancy-associated plasma protein-A (PAPP-A) gene IVS6+95 polymorphism and unstable angina pectoris
作者:
銭志宏1; 何国平1; 蔡高军1; 戚传平2; 高磊1; 沈丹丹1; 师干伟1
江苏大学附属武进医院:1.心内科，2中心实验室,江苏 常州 213002
Author(s):
QIAN Zhi-hong1;  HE Guo-ping1;  CAI Gao-jun1;  QI Chuan-ping2;  GAO Lei1;  SHEN Dan-dan1;  SHI Gan-wei1
1.Department of Cardiology, 2.Central Laboratory, Affiliated Wujin Hospital, Jiangsu University, Changzhou 213002, Jiangsu, China
关键词:
不稳定型心绞痛; 妊娠相关血浆蛋白-A; 基因多态性
Keywords:
pregnancy-associated plasma protein-A;  gene polymorphism;  unstable angina pectoris
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的: 探讨苏皖地区汉族人群妊娠相关血浆蛋白-A（PAPP-A）基因IVS6+95（C/G）多态性与不稳定型心绞痛(UAP)的相关性。方法： UAP组172例，对照组（行冠脉造影排除冠状动脉病变者）156例，采用苯酚-氯仿法提取DNA，聚合酶链反应-限制性片段长度多态性方法(PCR-RFLP)分析PAPP-A基因IVS6+95多态性，收集临床资料，并检测血糖和血脂等生化指标。结果： UAP组PAPP-A基因IVS6+95中CC基因型频率明显高于对照组(P<0.05)；对多个危险因素行多元Logistic回归分析，示PAPP-A基因IVS6+95单核苷酸多态性CC基因型与UAP有相关性（P<0.05）。结论： PAPP-A基因IVS6+95 CC基因型与苏皖地区汉族人群UAP的易感性有明显关系。
Abstract:
AIM: To investigate the association between pregnancy-associated plasma protein-A (PAPP-A) gene IVS6+95 polymorphism and unstable angina pectoris (UAP) in Chinese Han population in the Suwan region. METHODS: A total of 172 patients with UAP and 156 control subjects without coronary artery disease were recruited into the study. The PAPP-A IVS6+95 polymorphism gene was determined by polymerase chain reaction and restriction fragment length polymorphism analysis (PCR-RFLP). Clinical data and biochemical indicators of blood sugar and blood lipids were collected. RESULTS: Statistical difference was observed in the frequencies of CC and CG, GG genotype between UAP group and control group (P<0.05). Multivariate logistic regression analysis indicated a significant correlation between PAPP-A gene IVS6+95 polymorphism CC and UAP (P<0.05). CONCLUSION: PAPP-A gene IVS6+95 polymorphism is strongly associated with UAP in Chinese Han population in the Suwan region.

参考文献/References

［1］Bayes-Genis A, Conover CA, Overgaard MT, et al. Pregnancy associated plasma protein-A as a marker of acute coronary syndromes［J］. N Engl J Med, 2001, 345(14):1022-1029.

［2］ Miedema MD, Conover CA, MacDonald H, et al. Pregnancy Associated Plasma Protein-A Elevation in Patients With Acute Coronary Syndrome and Subsequent Atorvastatin Therapy［J］. Am J Cardiol, 2008, 101(1):35-39.

［3］郑卫星，罗助荣,黄明芳,等. PAPP-A变化在冠心病心绞痛危险度分层中的作用［J］. 中华急诊医学杂志， 2008， 17（3）：240-243.

［4］Park S, Youn JC, Shin DJ, et al. Genetic polymorphism in the pregnancy associated plasma protein-A associated with acute myocardial infarction［J］. Coron Artery Dis, 2007, 18(6):417-422.

［5］Boldt HB, Conover CA. Pregnancy-associated plasma protein-A (PAPP-A): A local regulatorof IGF bioavailability through cleavage of IGFBPs［J］. Growth Horm IGF Res, 2007, 17(1):10-18.

［6］Iversen KK, Teisner AS, Teisner B, et al. Pregnancy associated plasma protein A, a novel, quick, and sensitive marker in ST-elevation myocardial infarction［J］. Am J Cardiol, 2008, 101(10):1389 -1394.

［7］Lawrence JB, Oxvig C, Overgaard MT, et al. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A［J］. Proc Natl Acad Sci U S A, 1999, 96(6):3149-3153.

[8] Qin QP, Laitinen P, Majamaa-Voltti K, et al. Release patterns of pregnancy associated plasma protein-A ( PAPP-A) in patients with acute coronary syndromes［J］. Scand Cardiovasc J, 2002, 36(6):358-361.

[9] Newby LK. Cardiac marker testing: where should we focus?［J］. Am Heart J, 2000, 140(3):351-352.

备注/Memo

备注/Memo:
收稿日期：2009-12-01.通讯作者：何国平，主任医师，主要从事心血管内科临床、介入和分子生物学研究Email:guopinghe6@sina.com 作者简介：銭志宏，硕士生Email:qianzhihong7@sina.com
更新日期/Last Update: 2010-08-22