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Title:: Correlation between tumor necrosis factor-α and depression in elderly patients with coronary heart disease

作者:: 帕丽达·阿布来提; 胡尔西达·那斯尔; 古丽扎尔·买买提明; 刘宇; 新疆医科大学第一附属医院干部心血管二科，新疆乌鲁木齐 830054

Author(s):: PA Li da; HU Erxida; GU Li zaer; LIU Yu; Second Department of Cardiology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang, China

关键词:: 冠状动脉疾病; 抑郁; 肿瘤坏死因子

Keywords:: coronary disease; depression; tumor necrosis factor

分类号:: R541.4;R749.2

DOI:: -

文献标识码:: A

摘要:: 目的: 调查住院老年冠心病患者的抑郁情绪；初步探讨老年冠心病患者肿瘤坏死因子（TNF）的改变及抑郁对TNF的影响。方法: 连续收集2008年8月～11月住院的老年冠心病患者214例。根据中国精神疾病分类与诊断标准第三版（CCMD-3），将纳入患者分为冠心病并发抑郁组54例，冠心病不伴抑郁组160例。测量各生化指标，ZUNG抑郁自评量表得分和TNF值，观察各组血清TNF水平及血清TNF水平与抑郁得分的相关性。结果: 冠心病并发抑郁症组TNF值高于冠心病非抑郁组（P<0.05）；TNF与抑郁得分呈正相关（r=0.424，P<0.01）。控制白细胞计数与C-反应蛋白后，TNF仍与抑郁得分呈正相关（r=0.344，P=0.000）。结论: 老年冠心病并发抑郁患者TNF水平增高。

Abstract:: AIM: To investigate depression and changes of tumor necrosis factor alpha (TNF-α) level in elderly patients with coronary heart disease (CHD) and the impact of depression on TNF-α. METHODS: A total of 214 cases with stable angina were included in our study. According to diagnostic criteria from the Chinese Classification of Mental Disorders, the third edition (CCMD-3), the patients were divided into two groups: CHD group and depression (n=54) and CHD group without depression (n=160). Fifty healthy subjects were randomly used as control group. Biochemical indexes, ZUNG self-rating depression scale scores and TNF values were measured and the differences of TNF in different groups and the relationship between tumor necrosis factor-α (TNF-α) and depression scores were explored. RESULTS: TNF level in CHD group with depression was significantly higher than that in CHD group without depression (P<0.05). TNF and depression scores were positively correlated (r=0.424, P<0.01). After controlling WBC and C-reactive protein, TNF and depression scores remained positively correlated (r=0.344, P=0.000). CONCLUSION: The level of tumor necrosis factor increases in elderly CHD patients with depression.

参考文献/References

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老年冠心病患者抑郁与肿瘤坏死因子-α水平有相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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