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|本期目录/Table of Contents|

冠心病并发抑郁与血清白介素-6水平的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2011年第1期
页码:
116-119
栏目:
临床研究
出版日期:
2010-10-27

文章信息/Info

Title:
Relationship of serum interleukin-6 level with coronary heart disease accompanied by depression
作者:
麦合布拜木·麦麦提1; 帕丽达·阿布来提2; 库木斯3; 古丽扎尔·买买提明2
1.喀什地区人民医院心内科，新疆 喀什 844000；新疆医科大学第一附属医院： 2.干部心血管二科，3.心身科,新疆 乌鲁木齐 830054
Author(s):
MAIHE Bu bai mu1;  PA Li da2;  KU Musi3;  GU Li zaer2
1.Department of Cardiology, People’s Hospital of Ka Shi, Ka Shi 844000, Xinjiang, China; 2.Second Department of Cardiology, 3.Department of Psychosomatics, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang, China
关键词:
冠状动脉疾病; 抑郁; 白介素IL-6
Keywords:
coronary disease;  depression;  interleukin-6
分类号:
R392.12
DOI:
-
文献标识码:
A
摘要:
目的: 分析冠心病(CHD)患者的心理状况，探讨血清白介素-6（IL-6）与CHD并发抑郁的关系，为临床提供CHD并发抑郁干预治疗的依据。方法： 对90例CHD患者进行ZUNG抑郁自评量表 (SDS)评分，根据评分结果分为CHD伴有抑郁组(A组)与不伴抑郁组(B组)。用放射免疫法测定血清IL-6的水平，并记录年龄、性别、吸烟、文化程度、糖尿病、高血压病史及血脂水平等相关资料。结果： 入选的CHD患者57.58%伴有不同程度的抑郁，其中轻度抑郁者24例(26.67%)，中、重度抑郁者28例(31.11%)。男性患者57.79%伴有抑郁，女性患者57.89%伴有抑郁；男、女性CHD患者抑郁并存率之间的差异无统计学意义。A组患者血清IL-6的水平［M(P25,P75］为［0.04(0.01，0.06)］ μg/L，B组患者为［0.02(0.01，0.05)］ μg/L，A组高于B组，差异有统计学意义(P<0.05)。A组中、重度抑郁患者血清IL-6水平为［0.05(0.02，0.08)］ μg/L高于轻度抑郁IL-6水平为［0.04(0.01，0.05)］ μg/L，差异有统计学意义(P<0.05)。结论： CHD患者有较高的抑郁并存率，CHD伴有抑郁患者血清IL-6的水平明显高于不伴有抑郁患者，中、重度抑郁患者血清IL-6的水平明显高于轻度抑郁。CHD伴有抑郁是体内具有炎性反应的一个标志，也即炎性反应在CHD并发抑郁中起着一定的作用。
Abstract:
AIM: To explore the relationship between interleukin-6 (IL-6) and coronary heart disease (CHD) combined with depression for intervention strategies. METHODS: Ninety patients with CHD were recruited into the study and, according to ZUNG self-depression scale (SDS) scores, were divided into two groups: CHD combined with depression (group A) and CHD without depression (group B). Serum levels of IL-6 were measured by radioimmunoassay and personal data including age, gender, smoking habit, educational level, diabetes and hypertension history, and lipid levels were collected. RESULTS: It was found that 57.78% of the patients had varying degrees of depression, of whom 24 (26.67%) had mild depression and 28 (31.11%) had moderate and severe depression. Depression was found in 57.59% of the male patients and in 57.89% of female patients, with no statistical difference in the concomitance rate of depression between genders (P<0.05). Levels of serum IL-6 ［M(P25, P75)］ in group A ［0.04(0.01, 0.06)］ μg/L were significantly higher than in group B ［0.02 (0.01, 0.05)］ μg/L (P<0.05). In group A, the levels of serum IL-6 in patients with moderate and severe depression ［0.05 (0.02, 0.08)］ μg/L were higher than those in patients with mild depression ［0.04 (0.01, 0.05)］ μg/L (P<0.05). CONCLUSION: CHD patients with depression have a high concomitance rate. The level of IL-6 in CHD patients with depression is higher than in CHD patients without depression. In patients with moderate and severe depression the levels were higher than those in patients with mild depression. CHD combined with depression is a sign of activation of inflammatory responses. Inflammatory responses play a role in CHD combined with depression.

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备注/Memo

备注/Memo:
收稿日期：2009-09-16.基金项目：新疆维吾尔自治区自然科学基金项目（200721113） 通讯作者：古丽扎尔·买买提明，主任医师，主要从事心血管疾病与心理行为的相关研究 Email:lilac40157@sina.com 作者简介：麦合布拜木·麦麦提，住院医师，硕士Email:parida226@126.com
更新日期/Last Update: 2010-10-27