我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

肺动脉灌注HTK液在法乐氏四联症矫治术中的肺保护作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2011年第3期
页码:
379-382
栏目:
临床研究
出版日期:
2011-05-12

文章信息/Info

Title:
Lung perfusion with HTK solution relieves lung injury in corrections of Tetralogy of Fallot
作者:
李建安1; 刘迎龙2; 刘晋萍2; 李晓峰2
1.安徽医科大学附属安徽省立医院心脏外科，安徽 合肥 230001；2.北京协和医学院、中国医学科学院阜外医院儿童心脏外科中心,北京 100037
Author(s):
LI Jian-an1;  LIU Ying-long2;  LIU Jin-ping2;  LI Xiao-feng2
1.Department of Cardiovascular Surgery, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, Anhui, China; 2.Pediatric Center of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,
关键词:
肺损伤; HTK液; 体外循环; 法乐氏四联症
Keywords:
lung injury;  HTK solution;  cardiopulmonary bypass
分类号:
R654.1
DOI:
-
文献标识码:
A
摘要:
目的:评价体外循环(CPB)中肺动脉灌注低温HTK液对法乐氏四联征(TOF)患儿肺的保护作用。方法: 选取TOF患儿24例，随机分为肺动脉灌注组（n=12）和对照组（n=12），计算各组氧合指数(OI)和肺泡-动脉氧分压差(AaDO2)，硫代巴比妥酸反应法检测丙二醛(MDA)水平，ELISA法检测内皮素1(ET-1)、可溶性细胞间黏附分子-1(sICAM-1)和P-选择素水平。结果: 体外循环(CPB)后0、12、24、48 h，灌注组的OI均显著高于对照组（P<0.05，P<0.01），两组间变化的趋势有显著差异（P<0.05，P<0.01）；灌注组的AaDO2均显著低于对照组（P<0.05，P<0.01）；两组间CPB后MDA、ET-1、sICAM-1和P-选择素的水平变化趋势均有显著差异（P<0.05，P<0.01）。结论: CPB中肺动脉灌注低温HTK液可有效地减轻内皮细胞损伤，提高TOF矫治术后患儿的肺换气功能，改善预后。
Abstract:
AIM:To evaluate the protective effect of pulmonary perfusion with hypothermic HTK solution on lung function after cardiopulmonary bypass in corrections of tetralogy of Fallot. METHODS: Twenty-four consecutive infants with tetralogy of Fallot were randomly divided into perfusion group (n=12) and control group (n=12). Oxygen index, alveolar-arterial O2 gradient, serum levels of malondialdehyde, endothelin-1, sICAM-1, and P-selectin were measured before commencement and serially for 48 h after termination of bypass. RESULTS: Oxygenation values were better preserved in perfusion group than in control group. The trend revealed significant differences in serum levels of malondialdehyde, endothelin-1, sICAM-1, and P-selectin between groups. Serum levels of malondialdehyde, sICAM-1, and P-selectin tended to increase after bypass in control group, but remained at a low level in perfusion group. Serum levels of endothelin-1 increased significantly from 12 h after bypass in both groups and the levels in control group were significantly higher than those in perfusion group. CONCLUSIONS: This study suggests that pulmonary perfusion with hypothermic HTK solution during cardiopulmonary bypass relieves lung injury in infants with tetralogy of Fallot.

参考文献/References

[1]Siepe M,Goebel U,Mecklenburg A,et al.Pulsatile pulmonary perfusion during cardiopulmonary bypass reduces the pulmonary inflammatory response[J].Ann Thorac Surg,2008, 86(1):115-122.
[2]Zheng JH,Xu ZW,Wang W,et al.Lung perfusion with oxygenated blood during aortic clamping prevents lung injury[J].Asian Cardiovasc Thorac Ann,2004,12(1):58-60.
[3]Wei B,Liu Y,Wang Q,et al.Lung perfusion with protective solution relieves lung injury in corrections of Tetralogy of Fallot[J].Ann Thorac Surg,2004,77(3):918-924.
[4]Ege T,Huseyin G,Yalcin O,et al.Importance of pulmonary artery perfusion in cardiac surgery[J].J Cardiothorac Vasc Anesth,2004,18(2):166-174.
[5]Sakata J,Morishita K,Ito T,et al.Comparison of clinical outcome between histidine-triptophan-ketoglutalate solution and cold blood cardioplegic solution in mitral valve replacement[J].J Card Surg,1998,13(1):43-47.
[6]Schulz U,Morshuis M,Godo A,et al.Organ preservation in heart and heart-lung transplantation using HTK-Bretschneider solution[C].Proceedings of the World Society of Cardio-Thoracic Surgeons 8th World Congress. Houston,1998:132.
[7] Zhou W,Zeng D,Chen R,et al.Limb ischemic preconditioning reduces heart and lung injury after an open heart operation in infants[J].Pediatr Cardiol,2010,31(1):22-29.
[8]Comellas AP,Briva A.Role of endothelin-1 in acute lung injury[J].Transl Res,2009,153(6):263-271.
[9]Flori HR,Ware LB,Glidden D,et al.Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation[J].Pediatr Crit Care Med,2003,4(3):315-321.
[10]Koh TW,DeSouza AC,Pepper JR. The adhesion molecule P-selectin and cardiovascular disease-cardiac surgical implications[J].Eur Heart J,2004,25(11):993.

备注/Memo

备注/Memo:
收稿日期：2010-04-06.基金项目：国家“十一五”计划基金资助课题（2004BA709B07） 通讯作者：刘迎龙，主任医师，主要从事心血管外科研究Email：jianan1993@sohu.com 作者简介：李建安，主治医师Email：yuesefu@msn.com
更新日期/Last Update: 2011-03-17