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作者:: 尹霞; 赵昕综述; 郑杨审校; 吉林大学第一医院心血管疾病诊疗中心,吉林长春 130021

Author(s):: -

关键词:: 再灌注损伤; 急性心肌梗死; 糖尿病; 糖原合成酶激酶-3β; 锌

Keywords:: -

分类号:: R619.9

DOI:: -

文献标识码:: A

摘要:: 再灌注损伤（RI）是影响急性心肌梗死(AMI)预后的重要因素，而糖尿病(DM)并发RI的比例进一步增高。DM时糖原合成酶激酶-3β(GSK-3β)的水平升高，可导致线粒体通透性转换孔(mPTP)过度开放而加重RI；同时，DM通过影响缺血后适应时救援激酶途径而使后适应的保护作用减弱。锌作为GSK-3β的抑制剂，有望成为保护并发AMI的DM患者避免RI的临床理想用药。

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参考文献/References

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糖尿病与急性心肌梗死缺血再灌注损伤(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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