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急性冠状动脉综合征病变程度与血清骨保护素和脑钠尿肽水平有相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2011年第4期
页码:
472
栏目:
临床研究
出版日期:
2011-08-25

文章信息/Info

Title:
Relation between osteoprotegerin and B-type natriuretic peptide levels in patients with acute coronary syndrome
作者:
罗助荣; 张克己; 林毅; 郑磊磊; 徐高阳; 盖晓波
南京军区福州总医院、福建医科大学附属福总临床医学院心内科，福建 福州 350025
Author(s):
LUO Zhu-rong;  ZHANG Ke-ji;  LIN Yi;  ZHENG Lei-lei;  XU Gao-yang;  GAI Xiao-bo
Department of Cardiology, Fuzhou General Hospital, Nanjing Military Area Command & Cardiology Division, Fujian Medical University, Fuzhou 350025, Fujian, China)
关键词:
急性冠脉综合征; 骨保护素; 脑钠尿肽; 冠状病变程度
Keywords:
acute coronary syndrome;  osteoprotegerin;  B-type natriuretic peptide;  coronary artery disease extension
分类号:
R541.4
DOI:
61-1268/R.20110503.1518.013
文献标识码:
A
摘要:
目的:探讨血清骨保护素(OPG)和脑钠尿肽(BNP)水平与急性冠状动脉综合征的关系。方法： 160例患者分为2组：急性冠脉综合征（ACS）90例，对照组70例；入院时检测血浆OPG和BNP水平并进行冠脉造影。根据造影结果将冠状动脉狭窄的数目分为1支，2支，3支病变组并分析其与冠脉病变Gensini评分的相关性。结果： 与对照组相比ACS患者OPG、BNP水平都较高，差异有统计学意义（P<0.01），且随病变支数的增加显著升高。OPG与冠脉病变Gensini评分间存在显著的相关性(r=0.61，P<0.01)；BNP与冠脉病变Gensini评分也有相关性(r=0.34，P<0.01)。多元回归分析发现OPG与BNP与冠心病发生独立相关（均P<0.01 ）。结论： 血清OPG、BNP水平的升高与ACS病变程度有关。
Abstract:
AIM:To analyze the relation between osteoprotegerin (OPG) and B-type natriuretic peptide (BNP) levels in patients with acute coronary syndrome (ACS). METHODS: One hundred and sixty consecutive patients were classified into two groups: acute coronary syndrome (ACS) and control group. OPG and BNP were measured upon hospital admission and compared in relation to the number of narrowed coronary vessels (1-, 2-, 3-vessel disease) and to the degree of stenoses according to Gensini score. RESULTS: Serum OPG and BNP levels were significantly higher in patients than in controls (P<0.001) and the levels increased significantly with the degree of severity. A positive relation was found between OPG levels and Gensini score (P<0.01), whereas sRANKL levels and Gensini score and hs-CRP levels were negatively correlated (r=0.61, P<0.01). Only a mild correlation was found between BNP and Gensini score (r=0.34, P<0.01). Multiple regression analysis showed that OPG and BNP levels were independently and positively associated with the presence of coronary diseases (P<0.01 respectively). CONCLUSION: Serum OPG and BNP levels and the severity of ACS are related, suggesting that they may be involved in the process of coronary artery disease.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2010-10-15.基金项目:军队医学科技创新项目资助（09MA094） 作者简介:罗助荣,副主任医师Email:mdlzrong@126.com
更新日期/Last Update: 2011-06-02