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Title:: Correlation analysis of cardiovascular risk factors and degree of coronary artery stenosis in patients with coronary heart disease

作者:: 何星; 林国生; 武汉大学人民医院心内科，湖北武汉 430060

Author(s):: HE Xing; LIN Guo-sheng; Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, Hubei, China

关键词:: 冠状动脉疾病; 冠状动脉造影术; 危险因素

Keywords:: coronary disease; coronary angiography; risk factors

分类号:: R541.4

DOI:: 61-1268/R.20110503.1530.018

文献标识码:: A

摘要:: 目的:探讨冠状动脉病变程度与冠心病危险因素的相关性。方法：入选2010年1月～6月在武汉大学人民医院行冠状动脉造影的患者324例，其中确诊冠心病患者264例，排除冠心病者60例。冠脉病变程度由病变支数及病变Gensini总积分表示。收集患者性别、年龄、高血压病史、糖尿病病史、吸烟量（支数X年）、体质指数（BMI）、胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇（LDL-C）、心率（HR）、QT间期离散度（QTd）、病变冠脉支数、Gensini总积分，采用多因素和单因素分析。结果：单因素分析显示，在病变程度不同的各组间比较，随各组中单个危险因素病例百分率的增加，冠状动脉造影病变支数和病变Gensini总积分随之增加。多因素logistic回归分析（前进法）显示，QTd增大为冠心病病变程度的最显著的独立危险因素（OR=4.2,95%CI 3.8,4.4,P<0.01）,其他危险因素依次为低HDL-C、BMI增大、吸烟、增龄、糖尿病、高LDL-C、高血压病、高TC、高TG、HR增加和男性。结论： QTd增大为冠心病病变程度的最显著的独立相关因素，其他危险因素如低HDL-C、BMI增大、吸烟、增龄、糖尿病、高LDL-C、高血压病、高TC、高TG、心率增加和男性亦不能忽视。

Abstract:: AIM:To investigate the correlation between cardiovascular risk factors and coronary artery stenosis. METHODS: A total of 324 patients who underwent coronary angiography were selected from the People’s Hospital of Wuhan University from January 2010 to June 2010. There were 264 cases confirmed with coronary heart disease (CHD) (81.5%) and 60 cases without CHD (18.5%). Degree of coronary artery disease was assessed by the number of diseased vessels and total Gensini score. Data collected included gender, age, hypertension, diabetes, smoking, body mass index (BMI), cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), heart rate (HR), QT interval dispersion (QTd), coronary lesion count and total Gensini scores. Uni- and multivariate analyses were conducted. RESULTS: Univariate analysis showed that in groups of different lesions, coronary angiographic lesions and total Gensini score increased with the percentage increase of single risk factors. Multivariate logistic regression analysis (forward method) showed that increased QTd was the most significant independent risk factor for CHD (OR=4.2, 95% CI 3.8, 4.4, P<0.01), and other risk factors were low HDL-C, increased BMI, smoking, age, diabetes, high LDL-C, hypertension, high TC, high TG, increased HR, and male gender. CONCLUSION: Increased QTd is the most significant independent factor for CHD. Other risk factors such as low HDL-C, increased BMI, smoking, aging, diabetes, high LDL-C, hypertension, high TC, high TG, increased heart rate, and male gender should not be ignored.

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