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作者:: 李书凯¹; 李娟²; 孙新³; 翟蒙恩¹; 时歆¹; 张丙芳³; 裴建明²; 第四军医大学：1.口腔医学系十六队，2.基础生理学教研室，3.西京医院儿科，陕西西安710032

Author(s):: -

关键词:: κ-阿片肽; 低氧; 血管内皮功能; 一氧化氮; 肺动脉高压; 大鼠

Keywords:: -

分类号:: R363

DOI:: 61-1268/R.20110504.0936.003

文献标识码:: A

摘要:: 低氧性肺动脉高压（HPH）是慢性阻塞性肺病、慢性高原病和新生儿肺病等临床众多心、肺疾病发病的关键环节。我们前期研究证明了κ-阿片肽能够防治HPH。越来越多的证据显示：NO途径参与了HPH的发生和发展。本文结合我们前期研究就NO信号途径在κ-阿片受体介导的抗HPH的可能作用机制作一综述，可为认识防治HPH提供新的学术见解。

Abstract:: -

参考文献/References

[1]Sun X,Ma S,Zang YM,et al.Vasorelaxing effect of U50,488H in pulmonary artery and underlying mechanism in rats[J].Life Sci,2006,78(21):2516-2522.
[2]Pei JM,Sun X,Guo HT,et al.U50,488H depresses pulmonary pressure in rats subjected to chronic hypoxia[J].J Cardiovasc Pharmacol TM,2006,47(4):594-598.
[3]孙新,苏慧,臧益民,等.U50-488H对低氧性肺动脉高压大鼠体内一氧化氮、内皮素及血管紧张素Ⅱ水平的影响[J].心脏杂志,2007,19(3):249-251,257.
[4]Li J, Zhang P,Zhang QY,et al.Effects of U50,488H on hypoxia pulmonary hypertension and its underlying mechanism[J].Vascul Pharmacol,2009,51(2-3):72-77.
[5]Pronko TP,Zinchuk VV.Effect of nebivolol on blood oxygen transport indices and endothelial dysfunction in patients with arterial hypertension[J].Clin Physiol Funct Imaging,2009,29(3):170-176.
[6]Han RN,Stewart DJ.Defective lung vascular development in endothelial nitric oxide synthase-deficient mice[J].Trends Cardiovasc Med,2006,16(1):29-34.
[7]Skoro-Sajer N, Hack N,Sadushi-Kolii R,et al.Pulmonary vascular reactivity and prognosis in patients with chronic thromboembolic pulmonary hypertension: a pilot study[J].Circulation,2009,119(2):298-305.
[8]Matheis G,Sherman MP,Buckberg GD,et al.Role of L-Argine nitric oxide pathway in myocardial reoxygenation injury[J].Am J Physiol,1992,262(2 Pt 2):H616-H620.
[9]Berges A,Van Nassauw L,Bosmans J, et al.Role of nitric oxide and oxidative stress in ischemic myocardial injury and preconditioning[J].Acta Cardiol,2003,58(2):119-132.
[10]Dimmeler S,Haendeler J,Nehls M, et al.Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme(ICE)-like and cysteine protease protein (CPP)-32-like proteases[J].J Exp Med,1997,185(4):601-607.
[11]Rossig L,Haendeler J,Hermann C,et al.Nitric oxide down-regulates MKP-3 mRNA levels:involvement in endothelial cell protection from apoptosis[J].J Biol Chem,2000,275(33):25502-25507.
[12]易斌,钱桂生,白莉,等.缺氧致大鼠肺动脉平滑肌细胞Akt mRNA表达的变化[J].第三军医大学学报,2006,28(3):192-194.
[13]Ma H,Zhang HF,Yu L,et al.Vasculoprotective effect of insulin in the ischemic/reperfused canine heart: Role of Akt-stimulated NO production[J].Cardiovasc Res,2006,69(1):57-65.
[14]Knock GA,Snetkov VA, Shaifta Y,et al.Superoxide constricts rat pulmonary arteries via Rho-kinase-mediated Ca(2+) sensitization[J].Free Radic Biol Med,2009,46(5):633-642.
[15]Liu JQ,Zelko IN,Erbynn EM, et al.Hypoxic pulmonary hypertension:role of superoxide and NADPHoxidase(gp91phox)[J].Am J Physiol Lung Cell Mol Physiol,2006,290(1):L2-L10.
[16]Zelinski LM,Ohgami Y,Chung E,et al.A prolonged nitric oxide-dependent,opioid-mediated antinociceptive effect of hyperbaric oxygen in mice[J].J Pain,2009,10(2):167-172.
[17]Chung E,Burke B,Bieber AJ,et al.Dynorphin-mediated antinociceptive effects of L-arginine and SIN-1 (an NO donor) in mice[J].Brain Res Bull,2006,70(3):245-250.
[18]Ding WG,Zhou HC,Cui XG,et al.Anti-apoptotic effect of morphine-induced delayed preconditioning on pulmonary artery endothelial cells with anoxia/reoxygenation injury[J].Chin Med J(Engl),2008,121(14):1313-1318.
[19]Luis M,Luca J,Veronica G,et al.Involvement of nitric oxide in the inhibition of bone cancer-induced hyperalgesia through the activation of peripheral opioid receptors in mice[J].Neuropharmacology,2007,53(1):71-80.
[20]陈迈,裴建明,李兰荪,等.U50,488H对大鼠腹主动脉的舒张作用及其机制[J].第四军医大学学报,2001,22(1):29-32.

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