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Ⅱ型糖尿病患者颈动脉粥样硬化与血尿酸、纤维蛋白原的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2011年第5期
页码:
626-628
栏目:
临床研究
出版日期:
2011-10-25

文章信息/Info

Title:
Relationship between carotid atherosclerosis with serum uric acid and fibrinogen in patients with type II diabetes mellitus
作者:
刘 萍; 王丽萍
西安市中心医院内分泌科,陕西 西安 710003
Author(s):
LIU Ping;  WANG Li-ping
Department of Endocrinology, Xi'an Central Hospital, Xi’an 710003, Shaanxi, China
关键词:
尿酸; 纤维蛋白原; 糖尿病; Ⅱ型; 颈动脉粥样硬化
Keywords:
type II diabetes mellitus;  uric acid;  fibrinogen;  carotid atherosclerosis
分类号:
R587.1
DOI:
-
文献标识码:
A
摘要:
目的:探讨Ⅱ型糖尿病(T2DM)患者血清尿酸（UA）、纤维蛋白原(Fg)水平是否与颈动脉粥样硬化(AS)有关。方法： T2DM患者218例,根据有无颈AS分为2组, 对患者年龄、病程、高血压病、UA、肌酐(Cr)、总胆固醇（TC）、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇（HDL-C）、糖基化血红蛋白和Fg等AS危险因素进行单因素和多因素分析。结果： logistic回归分析显示年龄、病程、UA、Cr、UA /Cr、LDL-C,Fg与T2DM颈AS有相关性。UA危险因素的多元逐步回归分析显示病程、颈AS、Cr、TG、TC与UA相关；Fg危险因素的多元逐步回归分析显示,颈AS与Fg相关。结论： T2DM颈AS患者血清中UA、Fg明显升高，是AS的危险因素。
Abstract:
AIM:To determine whether uric acid and fibrinogen are independent factors associated with carotid atherosclerosis in patients with type II diabetes mellitus (T2DM). METHODS: A total of 218 T2DM patients with or without carotid atherosclerosis were examined. Serum uric acid, fibrinogen, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein and HbA1c levels were determined. Other risk factors including age, T2DM duration, and blood pressure (systolic and diastolic) were observed. RESULTS: Logistic regression analysis of carotid atherosclerosis showed that uric acid and fibrinogen were higher in the group with carotid atherosclerosis. Uric acid together with fibrinogen, age, T2DM duration, blood pressure, creatinine, low-density lipoprotein and UA/Cr was associated with carotid atherosclerosis in patients with T2DM. Multiple regression analysis of uric acid in all groups showed that T2DM duration, creatinine, serum total cholesterol, triglyceride and carotid atherosclerosis were independent determinants. Multiple regression analysis of fibrinogen in all groups showed that carotid atherosclerosis was an independent determinant. CONCLUSION: Uric acid and fibrinogen are higher in carotid atherosclerosis patients and are likely risk factors in patients with T2DM with carotid atherosclerosis.

参考文献/References

[1]Ishizaka N,Ishizaka Y,Toda E,et al.Association between serum uric acid，metabolic syndrome and carotid atherosclerosis in Japanese individuals[J].Arterioscler Thromb Vasc Biol,2005,25(5):1038-1044.

[2]李 岩,赵 冬,刘 静，等.高尿酸血症与新发颈动脉粥样硬化斑块的关系[J].中华内科杂志,2008,47（11）：906-909.

[3]Suama C,Dean RT,May J,et al.Human atheroscleroti plaque Contains both oxidized lipids and relatively large amounts of alpha-tocopherol and ascorbate[J].Arterioscler Thromb Vasc Biol,1995,15(10):1616-1624

[4]薛长春.2型糖尿病血尿酸水平及其并发症相关因素分析[J].中国全科医学,2007,10(22):1868-1869.

[5]Kofoed SC,Wittrup HH,Sillesen H,et al.Fibrinogen predicts ischaemic stroke and advanced atherosclerosis but not echolucent, rupture- prone carotid plaques: the Copenhagen City Heart Study[J].Eur Heart J,2003, 24(6):567-576.

[6]Maresca G,Di Blasio AD,Marchili R,et al.Measuring plasma fibrinogen to predict stroke and myocardial infarction, an update[J].Arterioscler Thromb Vasc Biol,1999, 19(6):1368-1377.

备注/Memo

备注/Memo:
收稿日期：2010-12-21.作者简介：刘萍，副主任医师，硕士Email:pinghao-123@163.com
更新日期/Last Update: 2011-11-03