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|本期目录/Table of Contents|

河南地区冠心病患者ApoB/apoA-I与颈动脉内膜中层厚度的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2011年第6期
页码:
737-740
栏目:
临床研究
出版日期:
2011-12-25

文章信息/Info

Title:
Relationship between ApoB/apoA-I ratio and carotid artery intima-media thickness in patients with coronary heart disease in the Henan Region of China
作者:
王宪沛; 李 炜; 高传玉; 李牧蔚; 顾爱丽; 肖文涛; 晏娟娟
河南省人民医院心内科、河南省心血管流行病学研究所,河南 郑州 450003
Author(s):
WANG Xian-pei;  LI Wei;  GAO Chuan-yu;  LI Mu-wei;  GU Ai-li;  XIAO Wen-tao;  YAN Juan-juan
Department of Cardiovascular Diseases, Henan Provincial People’s Hospital & Institute of Cardiovascular Epidemiology of Henan province, Zhenzhou 450003, Henan, China
关键词:
冠状动脉疾病; 载脂蛋白ApoB/apoAI; 血脂谱; 河南地区; 颈动脉内膜中层厚度
Keywords:
coronary disease;  apolipoprotein ApoB/apoA-I;  lipid profile;  central plains region of China;  carotid artery intima-media thickness
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:分析河南地区冠心病患者血脂谱特征及载脂蛋白B(ApoB)/载脂蛋白A-I(ApoA-I)比值与颈动脉内膜中层厚度（cIMT）关系。方法： 冠脉造影确诊的正常对照组和冠心病患者，进行血脂及载脂蛋白生化分析，B型超声测量cIMT，统计学分析性别分组和ApoB/apoA-I比值分组血脂谱特征和cIMT的差异。多元回归分析cIMT和血脂谱的关系。结果： ①以性别分组的冠心病患者中，高密度脂蛋白胆固醇（HDL-C）、ApoA-I、ApoB/apoA-I、低密度脂蛋白胆固醇（LDL-C）/HDL-C、总胆固醇（TC）/HDL-C和cIMT在男女两组有显著差异（均P<0.05）。②以ApoB/apoA-I比值分组（男性截断点0.8，女性截断点0.7）的冠心病患者，年龄和他汀治疗率在ApoB/apoA-I比值低的男女两组均高于比值高的组（均P<0.05），糖尿病、吸烟、饮酒、cIMT和其他血脂谱指标在ApoB/apoA-I比值高的男女两组均高于比值低的组（均P<0.05）。③多元回归分析显示，仅ApoA-I、ApoB和ApoB/apoA-I回归系数有统计学差异（均P<0.05）。结论： 冠心病患者cIMT与ApoB/apoA-I比值显著相关。ApoB/apoA-I比值反映cIMT的敏感性比LDL-C更好。
Abstract:
AIM:To study the characteristics of lipid profile and the relationship between ApoB/apoA-I ratio and carotid artery intima-media thickness (cIMT) in patients with coronary heart disease (CHD) in the Henan Region of China in order to provide evidence for risk factor appraisal and efficiency of medical therapy. METHODS: Serum lipid and apolipoprotein of CHD patients confirmed by coronary angiography were biochemically analyzed. B-mode carotid ultrasonography of cIMT was performed in 812 patients. The differences of lipid profile and cIMT in gender-based groups and ApoB/apoA-I ratio-based groups were analyzed statistically. The relationship between cIMT and lipid profile was studied by multiple regression analysis. RESULTS: In gender-based CHD patients, a significant difference was observed in HDL-C, ApoA-I, ApoB/apoA-I, LDL/HDL, TC/HDL and cIMT between groups (all P<0.05). In ApoB/apoA-I ratio-based CHD patients (the cut-off value for males was 0.8 and for females was 0.7), age and percentages of treatment with statins were higher in low ApoB/apoA-I ratio group than those in high ratio group (P<0.05). However, the percentage of diabetes mellitus, smoking, alcohol consumption, cIMT and other lipid profile indexes were higher in high ApoB/apoA-I ratio group than those in the low ratio group (P<0.05), Multiple regression analysis showed only significant difference in the regression coefficient of ApoA-I, ApoB and ApoB/apoA-I (P<0.05). CONCLUSION: cIMT is significantly correlated with ApoB/apoA-I ratio in CHD patients. ApoB/apoA-I ratio is a more sensitive correlation index with cIMT than LDL-c.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2011-05-02.通讯作者：高传玉，主任医师，主要从事冠心病诊治的研究Email：dugusiliang@163.com 作者简介：王宪沛，主治医师，博士Email：xianpei_wang@163.com
更新日期/Last Update: 2011-12-27