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|本期目录/Table of Contents|

平滑肌细胞钙离子相关通道与血管重构性疾病

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2011年第6期
页码:
807-810
栏目:
综述
出版日期:
2011-12-25

文章信息/Info

Title:
-
作者:
李慧颖; 张 毅; 杨绍松; 董 玲
第四军医大学基础部生理学教研室，陕西 西安 710032
Author(s):
-
关键词:
血管平滑肌细胞; 离子通道; 血管重构性疾病
Keywords:
-
分类号:
R329.25
DOI:
-
文献标识码:
A
摘要:
血管重构性疾病形成和发展的根本原因之一是血管平滑肌细胞(vascular smooth muscle cells,VSMC）发生表型转化（由收缩型转变为合成型），丧失收缩功能而获得增殖、迁移的能力。在此过程中，VSMC上多种钙离子相关通道：如L-型钙离子通道（L-Ca通道）、瞬时受体电位通道（TRPC）、三磷酸肌醇受体(IP3R)通道及钙激活的钾(KCa)通道等发生功能、数量和通道结构上的改变。本文关注的是不同离子通道的相应变化，以期对该类型疾病的发病机制及可能的药物治疗提供理论的依据。
Abstract:
-

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2011-03-20.基金项目：国家自然科学基金课题资助（30800432）；陕西省中医管理局中医药科研课题资助（jc38） 通讯作者：董玲，讲师，主要从事糖尿病与心血管损害的研究Email：dongling@fmmu.edu.cn 作者简介：李慧颖，本科生Email：dongling@fmmu.edu.cn
更新日期/Last Update: 2011-12-27