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Title:: Relationship between Helicobacter pylori infection and coronary artery disease

作者:: 啜玉彩¹; 宋宏鲁²; 薛明涛¹; 宁晓喧¹; 何争³; 李源¹; 王晓明¹; (第四军医大学西京医院：1.老年病科，3.心脏内科，陕西西安 710033；2.解放军66220部队医院，河北邢台市 054000)

Author(s):: CHUAI Yu-cai¹; SONG Hong-lu²; XUE Ming-tao¹; NING Xiao-xuan¹; HE Zheng³; LI Yuan¹; WANG Xiao-ming¹; (1.Department of Geriatrics, 3.Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710033, Shaanxi; 2.PLA Hospital of Unit 66220, Xingtai 054000, Hebei, China)

关键词:: 幽门螺杆菌; 冠状动脉疾病

Keywords:: Helicobacter pylori; coronary disease

分类号:: R541.4

DOI:: -

文献标识码:: A

摘要:: 目的:探讨幽门螺杆菌（helicobacter pylori,Hp）感染与冠心病之间的关系。方法：研究对象分为：正常对照组（88例）和冠心病组（175例），正常对照组为冠状动脉造影（CAG）正常者；冠心病组经CAG证实冠状动脉狭窄程度超过50%，且排除Hp感染根治史或者恶性肿瘤的病史。我们通过胃十二指肠镜活检制作胃窦部组织切片，Warthin-starry银染色确定Hp感染。结果：两组间观测指标性别、年龄、吸烟和高密度脂蛋白胆固醇（HDL-C）差异具有统计学意义。正常对照组中28例（32%）和冠心病组73例（42%）伴有Hp感染，但差异不具有统计学意义。随访行经皮冠状动脉介入治疗的冠心病患者82例，半年复查CAG，59例Hp阴性的患者有21例(36%)出现新的冠状动脉病变或支架内再狭窄，23例Hp阳性的患者有12例（52%）出现新的冠状动脉病变或支架内再狭窄，两组间差异不具有统计学意义。结论：本研究没有明确Hp感染与冠心病的关系，有待进一步研究。

Abstract:: AIM:To investigate the relationship between Helicobacter pylori (Hp) infection and coronary artery disease (CAD). METHODS: There were 263 cases divided into two groups. There were 88 cases in the normal group and 175 cases in the CAD group. Patients in the CAD group had >50% coronary stenosis diagnosed by coronary angiography. Those patients with a history of previous Hp eradication and/or malignancy were ruled out. The tissue was acquired by gastroduodenoscopic biopsy and then stained by Warthin-starry silver stain. RESULTS: There were significant differences between groups in gender, age, smoking habit and high-density lipoprotein cholesterol (HDL-C). There was no statistical difference in Hp infection ratio between groups (32% vs. 42%). Six months later, 82 patients of the CAD group who had been treated by percutaneous coronary intervention (PCI) experienced angiography once again. Twenty-one (36%) of the 59 patients of the Hp-negative group and 12 (52%) of the 23 patients of the Hp-positive group experienced new coronary stenotic lesion and in-stent restenosis. There was no statistical significance. CONCLUSION: There was no definite relationship between Hp infection and CAD. Further studies are needed in this area.

参考文献/References

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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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