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|本期目录/Table of Contents|

急性冠脉综合征行急诊PCI术后hs-CRP和NT-proBNP的临床意义及其预测价值(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第1期
页码:
63-66
栏目:
临床研究
出版日期:
2012-02-25

文章信息/Info

Title:
Clinical significance and predictive value of high sensitivity C-reactive protein and N-terminal pro-brain natriuretic peptide in patients with acute coronary syndrome after primary percutaneous coronary intervention
作者:
罗 巍1; 丁家崇1; 周海依2
(1.马王堆医院心血管一区，湖南 马王堆 410016；2.长沙市中心医院胸二科，湖南 长沙 410000)
Author(s):
LUO Wei1;  DING Jia-chong1;  ZHUO Hai-yi2
(1.Department of Cardiology, Mawangdui Hospital of Hunan Province, Changsha 410016, Hunan, China; 2.Department of Chest, Changsha Central Hospital, Changsha 410000, Hunan, China0
关键词:
急性冠脉综合征; 高敏C反应蛋白; 氨基末端脑钠尿肽原
Keywords:
acute coronary syndrome;  high sensitivity C-reactive protein;  N-terminal pro-brain natriuretic peptide
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:观察高敏C反应蛋白（hs-CRP）和氨基末端脑钠尿肽原（NT-proBNP）在急性冠脉综合征（ACS）行急诊冠状动脉介入治疗（PCI）术前后的临床意义及其近期预后的预测价值。方法: 选择从2009年2月~2011年4月入住两家医院的ACS患者101例，均已成功行急诊PCI术，术后24 h、72 h~7 d、3~6个月测定血清hs-CRP和NT-proBNP水平；并观察随访3~6个月的主要心脏不良事件（MACE）。同时观察ACS药物治疗组52例，健康对照组40例，并进行对比分析。结果: 药物治疗组的近期血清NT-proBNP水平显著高于PCI组；而药物治疗组的72 h~7 d的血清hs-CRP水平显著高于PCI组；近期PCI组的MACE事件低于药物治疗组。结论: 急诊PCI组3~6个月内治疗效果优于药物治疗组。血清NT-proBNP能够对ACS患者进行危险分层，预测MACE的发生率；hs-CRP可作为行急诊PCI的ACS患者的近期预后的预测因子。
Abstract:
AIM:To investigate the clinical significance and predictive value of high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-brain natriuretic peptide in patients with acute coronary syndrome (ACS) after primary percutaneous coronary intervention (PCI). METHODS: We summarized consecutive patients with ACS from February 2007 to April 2011 in Hunan Mawangdui Hospital and Changsha Central Hospital. A total of 101 ACS patients successfully underwent primary PCI and in whom plasma hs-CRP and NT-proBNP were measured, respectively, 24 h, 72 h-7 days and 3-6 months after PCI. Major adverse cardiac events (MACE) were observed during hospitalization and within 3-6 months after PCI. Plasma hs-CRP and NT-proBNP levels as well as incidence of MACE in 52 ACS patients in medically treated group and 40 healthy controls were also examined during the same period and compared with those in PCI group. RESULTS: Short-term plasma NT-proBNP levels in medically treated group were significantly higher than those in PCI group, but plasma hs-CRP levels within 72 h-7 days were significantly higher in PCI group compared with those in medicine treatment group. MACE in PCI group was lower than that in medically treated group. CONCLUSION: Both plasma hs-CRP and NT-proBNP are good predictors for mortality and MACE incidence in ACS patients treated with PCI or medications. hs-CRP is a short-term prognostic factor for ACS patients treated with primary PCI, whereas NT-proBNP is a long-term prognostic factor for ACS patients.

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备注/Memo

备注/Memo:
收稿日期：2011-07-27.作者简介：罗巍，主治医师，硕士生 Email:ljy.5020@163.com
更新日期/Last Update: 2012-02-14