我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

计算机模拟异常血钾浓度对兔窦房结起搏活性的影响及其调控(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第2期
页码:
146-149,153
栏目:
基础研究
出版日期:
2012-04-25

文章信息/Info

Title:
Effect of abnormal K+ concentration on pacemaker activity of rabbit sinoatrial node and its control by computer simulation
作者:
王 萌; 张季谦; 马文洋; 李 翔
(安徽师范大学物理与电子信息学院计算物理教研室，安徽 芜湖 241000)
Author(s):
Wang Meng;  Zhang Ji-qian;  Ma Wen-yang;  Li Xiang
(Department of Computational Physics, College of Physics and Electronic Information, Anhui Normal University, Wuhu 241000, Anhui, China)
关键词:
窦房结; 血钾异常; 仿真模拟; 起搏活动
Keywords:
sinoatrial node;  abnormal serum potassium;  simulation;  pacemaker activity
分类号:
R322.11；TP391.9
DOI:
-
文献标识码:
A
摘要:
目的:研究不同血钾浓度水平对窦房结电生理活性的影响，以及在血钾异常条件下，钠、钙离子浓度及钙电流对窦房结起搏的调控作用。方法：以Zhang构建的兔子窦房结仿真模型为研究对象，通过改变模型中钾、钠、钙离子通道的电导及钾、钠离子的浓度等参数，对模型满足的微分方程进行数值计算。结果：检验了异常血钾浓度对窦房结电生理活性的影响；发现在高血钾条件下，血钠变化对起搏活性有明显的调节作用；在血钾浓度异常条件下，增大L和T型钙电流，可以有效地恢复窦房结活性。结论：模拟实验显示，适当提高血钠的浓度，可以调控高血钾条件下的窦房结活性；提高钙通道的活性，可以有效地改善血钾浓度异常条件下的窦房结起搏活动。
Abstract:
AIM:To study the effect of different potassium ion concentrations on the electrophysiological activity of the sinoatrial node (SAN) and the control of Na+ and Ca2+ on the pacemaker activity of SAN under the condition of abnormal K+ concentration. METHODS: We used the Zhang model of the rabbit SAN. By changing the conductance of K+, Na+ and Ca2+, as well as their concentration, numerical calculations were then performed on the differential equations for this dynamic model. RESULTS: The effect of abnormal K+ concentration on electrophysiology of SAN was confirmed. It was found that under the hyperkalemia condition, changes in serum Na+ induced a significant regulating effect on pacing activity. Under the condition of abnormal K+ concentration, it restored pacemaker and conduction activity of SAN when increasing the L- and T-type Ca2+ current. CONCLUSION: Elevating Na+ concentration can enhance the activity of the SAN. Furthermore, pacemaker activity of SAN with abnormal K+ concentration can be effectively improved by increasing the activity of Ca2+ channels.

参考文献/References

[1]张 娟,成建华.哺乳动物心脏离子通道的分布、功能及其分子基础的研究进展[J].心脏杂志,2010,22(4):610-615.

[2]邓松柏,佘 强.窦房结自动除极相关离子通道的研究进展[J].心血管病学进展,2008,29(5):736-739.

[3]李慈珍,李沪生,刘远谋.兔窦房结细胞三种主要起搏离子流的作用[J].心脏杂志,2006,18(2):174-177.

[4]Hodgkin AL,Huxley AF.A quantitative description of membrane current and its application to conduction and excitation in nerve.1952[J].Bull Math Biol,1990,52(1-2):25-71.

[5]Clayton RH,Bernus O,Cherry EM,et al.Models of cardiac tissue electrophysiology:Progress,challenges and open questions[J].Prog Biophys Mol Biol,2011,104(1-3):22-48.

[6]Fink M,Niederer SA,Cherry EM,et al.Cardiac cell modelling:observations from the heart of the cardiac physiome project[J].Prog Biophys Mol Biol,2011,104(1-3):2-21.

[7]Zhang H,Holden AV,Kodama I,et al.Mathematical models of action potentials in the periphery and centre of the rabbit sinoatrial node[J].Am J Physiol,2000,279(1):H397-H421.

[8]Zhang H,Zhao Y,Lei M,et al.Computational evaluation of the roles of Na+ current,iNa,and cell death in cardiac pacemaking and driving[J].Am J Physiol Heart Circ Physiol,2007,292(1):H165-H174.

[9]于晓江,臧伟进,臧益民,等.乙酰胆碱对心脏窦房结脱敏的离子流分析[J].心脏杂志,2001,13(2):81-86.

[10]Zhang H, Holden AV,Noble D,et al.Analysis of the chronotropic effect of acetylcholine on sinoatrial node cells[J].J Cardiovasc Electrophysiol,2002,13(5):465-474.

[11]刑华雄.心电图基础[M].解放军出版社,1988:122-125.

[12]钟 敏,唐国宁.用钙离子通道激动剂抑制心脏组织中的螺旋波和时空混沌[J].物理学报,2010,59(5):3070-3076.

[13]Cantalapiedra IR,Pearanda A,Echebarria B,et al.Phase-2 reentry in cardiac tissue:Role of the slow calcium pulse[J].Phys Rev E Stat Nonlin Soft Matter Phys,2010,82(1 Pt 1):011907.

备注/Memo

备注/Memo:
收稿日期：2011-09-08.基金项目：国家自然科研基金理论物理专款项目资助(11047017)； 安徽省自然科研基金项目资助(2009KJ099B)；安徽师范大学创新团队科研基金项目资助(2009AKJ016) 通讯作者：张季谦，教授，主要从事复杂体系的非线性动力学研究 Email:zhangcdc@mail.ahnu.edu.cn 作者简介：王萌，硕士生 Email:dexter.wang@163.com
更新日期/Last Update: 2012-04-01