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|本期目录/Table of Contents|

肌节Z盘：心肌细胞的信号转导中心(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第2期
页码:
255-259
栏目:
综述
出版日期:
2012-04-25

文章信息/Info

Title:
Sarcomeric Z-disc: A center of signaling transduction in cardiomyocytes
作者:
余志斌
(第四军医大学航空航天生理学教研室，陕西 西安 710032)
Author(s):
YU Zhi-bin
(Department of Aerospace Physiology, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
肌节; 心肌细胞; Z盘; 信号转导
Keywords:
Z-disc;  signal transduction
分类号:
R322.74
DOI:
-
文献标识码:
A
摘要:
近年发现，除形成Z盘的骨架蛋白外，还有许多蛋白定位于Z盘，如结合或募集离子通道、Na-Ca交换体、蛋白激酶、蛋白磷酸酶、磷酸二酯酶、蛋白水解酶、组蛋白乙酰转移酶与组蛋白脱乙酰化酶等的蛋白分子，参与了多条信号转导通道的信号调节作用。Z盘还能感知心肌细胞的应力与应变，使结合其上的一些蛋白向核转位，调节基因表达。另外，T管穿行于Z盘之间，可使各类调节信号能快速发挥作用。因此，Z盘部位实质上成为心肌细胞中的信号转导中心。
Abstract:
Sarcomere represents the fundamental contractile unit of cardiomyocytes. The lateral boundaries of a single sarcomere are built up by Z-discs, which also represent a key interface between the contractile apparatus and the cytoskeleton. Z-discs provide a backbone for the insertions of actin-based thin filaments as well as titin and nebulin/nebulette. Z-discs can also transmit forces generated within the sarcomere to the extracellular matrix. In addition to the cytoskeletal proteins, Z-discs are composed of a large number of adaptor proteins and other molecules. These proteins can bind or recruit ion channels, Na-Ca exchanger, protein kinases, protein phosphatases, phosphodiesterases, proteases, acetylases and deacetylases, which are involved in multiple signal transduction pathways. Z-discs also sense the stress and strain from sarcomeres and drive nuclear translocation of some shuttle proteins that modulate gene expression. Transverse tubules are invaginations of the surface membrane that form a complex network surrounding myofibrils. Therefore, the transverse tubule network is a structure that allows rapid propagation of excitation and biochemical signals into Z-discs. In summary, Z-discs are a bona fide center of signal transduction in cardiomyocytes.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2011-08-31.基金项目：国家自然科学基金项目资助(31071044) 作者简介：余志斌，教授，博士 Email:yuzhib@fmmu.edu.cn
更新日期/Last Update: 2012-04-01