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Title:: Comparison of clinical outcomes of paclitaxel-loaded microporous stents vs. imported sirolimus-eluting stents for treatment of coronary heart disease

作者:: 李涛; 金鹏; 李光南; 温亮; 李佳欣; 任喜君; 李学奇; (哈尔滨医科大学第四附属院心内科六病房，黑龙江哈尔滨 150001)

Author(s):: LI Tao; JIN Peng; LI Guang-nan; WEN Liang; LI Jia-xin; REN Xi-jun; LI Xue-qi; (Department of Internal Medicine, Fourth Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China)

关键词:: 紫杉醇微孔载药支架; 雷帕霉素药物洗脱支架; 临床疗效

Keywords:: paclitaxel-loaded microporous stent; sirolimus-eluting stent; clinical outcomes

分类号:: R541.4

DOI:: -

文献标识码:: A

摘要:: 目的:比较紫杉醇微孔载药支架和进口雷帕霉素药物洗脱支架在经皮冠状动脉介入治疗中的临床疗效。方法: 筛选73例行经皮冠状动脉介入治疗术的冠心病患者，随机分为两组，紫杉醇微孔载药支架组（紫杉醇组，35例）和进口雷帕霉素药物洗脱支架组（雷帕霉素组，38例）。支架植入术后6个月复查冠状动脉造影（CAG）。随访6个月，对比两组支架内血栓形成、主要心血管不良事件（包括心源性死亡、非致死性心肌梗死、靶病变血运重建）和支架内再狭窄发生率。结果：随访6个月，两组均未出现急性、亚急性和晚期支架内血栓形成、非致死性心肌梗死和心源性死亡。心绞痛、支架内再狭窄和靶病变血运重建发生率均无统计学差异。结论：紫杉醇微孔载药支架与进口雷帕霉素药物洗脱支架在治疗冠状动脉简单病变时具有相同的近、中期临床疗效和安全性。

Abstract:: AIM:To compare the outcomes of paclitaxel-loaded microporous stents and imported sirolimus-eluting stents in the treatment of patients undergoing percutaneous coronary intervention (PCI). METHODS: Seventy-three patients who underwent PCI were randomly divided into two groups: 35 patients with paclitaxel-loaded microporous stent (paclitaxel stents) and 38 patients with imported sirolimus-eluting stents (sirolimus group). Coronary artery angiography (CAG) was performed in all patients after a 6-month follow-up period. The incidence of major adverse cardiac events (MACEs) including cardiac death, myocardial infarction and target lesion revascularization and in-stent restenosis rate were compared. RESULTS: During a 6-month follow-up, there were no acute, subacute, or late stent thromboses, nonlethal myocardial infarction or cardiac deaths in the two groups. Differences in angina, in-stent restenosis and target lesion revascularization were not statistically significant between groups. CONCLUSION: Paclitaxel-loaded microporous stents have the same clinical effects and safety as imported sirolimus-eluting stents for coronary artery disease in clinical outcomes in the short- and medium-term. Moreover, the cost-effectiveness ratio of paclitaxel-loaded microporous stents is higher.

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紫杉醇微孔载药支架与进口雷帕霉素药物洗脱支架治疗冠心病的临床效果比较(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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