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|本期目录/Table of Contents|

持续性心房颤动患者心率变异性与脑钠尿肽的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第4期
页码:
474-476
栏目:
临床研究
出版日期:
2012-08-25

文章信息/Info

Title:
Correlation between heart rate variability and brain natriuretic peptide in patients with persistent atrial fibrillation
作者:
李宏松; 石来新; 卢英民; 韦彩雯; 宋 蕾; 李志华; 蔡振东
(上海交通大学医学院附属新华医院（崇明）心内科，上海 202150)
Author(s):
LI Hong-song;  SHI Lai-xin;  LU Ying-min;  WEI Cai-wen;  SONG Lei;  LI Zhi-hua;  CAI Zhen-dong
(Department of Cardiology, Xinhua (Chongming) Hospital, Shanghai Jiaotong University, Shanghai 202150, China)
关键词:
心房颤动; 心率变异性; 脑钠尿肽
Keywords:
atrial fibrillation;  heart rate variability;  brain natriuretic peptide
分类号:
R541.71
DOI:
-
文献标识码:
A
摘要:
目的:探讨持续性心房颤动患者心率变异性与脑钠尿肽（BNP）的相关性。方法： 入选45例持续性心房颤动患者，20例正常对照组。行24小时动态心电图检查，检测心率变异性时域指标，并行BNP测定，再分析以上两者的相关性。结果： 持续性房颤患者与对照组比较，心率增快，心率变异性时域指标SDNN、RMSSD、PNN50显著增加（P<0.01）；平均RR间期（RINNT）实测值与BNP呈负相关；以平均心率矫正后的有关心率变异时域指标RMSSDDdiff和PNN50Ddiff与BNP呈正相关。结论： 持续性心房颤动患者心率变异性时域参数增加，BNP受心率和心率变异性改变的影响。
Abstract:
AIM:To investigate the correlation between heart rate variability and brain natriuretic peptide (BNP) in patients with persistent atrial fibrillation (AF). METHODS: Forty-five patients with persistent AF were placed into one group and 20 patients without persistent AF were placed in the normal control group. Twenty-four hour ECG was monitored for the time domain indexes of heart rate variability, and plasma BNP concentration was tested. Correlation between the time domain indexes and plasma BNP concentration was analyzed. RESULTS: In patients with persistent AF, the heart rate increased and heart rate variability time domain indexes (SDNN, RMSSD and PNN50) increased significantly (P<0.01). The actual RINNT was negatively correlated with plasma BNP concentration. After correction with the average heart rate, heart rate variability time domain indexes (RMSSDDdiff and PNN50Ddiff) were positively correlated with BNP concentration. CONCLUSION: In patients with persistent AF, the time domain parameters of heart rate variability increase and plasma BNP concentration is affected by the heart rate and the changes in heart rate variability.

参考文献/References

[1]Sosnowski M,Macfarlane PW,Tendera M.Determinants of a reduced heart rate variability in chronic atrial fibrillation[J].Ann Noninvasive Electrocardiol,2011,16(4):321-326.

[2]Wozakowska-Kapon B,Opolski G,Herman Z,et al.Natriuretic peptides in patients with atrial fibrillation[J].Cardiol J,2008,15(6):525-529.

[3]陈则君.持续性心房颤动患者心率变异性分析[J].临床医学,2011,31(5):57-58.

[4]Sosnowski M,Korzeniowska B,Macfarlane PW,et al.Relationship between R-R interval variation and left ventricular function in sinus rhythm and atrial fibrillation as estimated by means of heart rate variability fraction[J].Cardiol J,2011,18(5):538-545.

[5]Bakowski D,Wozakowska-Kaplon B, Opolski G.The influence of left ventricle diastolic function on natriuretic peptides levels in patients with atrial fibrillation[J].Pacing Clin Electrophysiol,2009,32(6):745-752.

备注/Memo

备注/Memo:
收稿日期：2012-02-17.通讯作者：石来新，副主任医师，主要从事高血压与心律失常的研究 Email：lymkkkk@yahoo.com 作者简介：李宏松，主治医师，硕士Email：xlys_hs@126.com
更新日期/Last Update: 2012-07-20