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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2012年第4期

页码:

535-538

栏目:

综述

出版日期:

2012-08-25

文章信息/Info

Title:

Expression and significance of angiopoietin/Tie2 system in angiogenesis and vascular maturation

作者:

衣 慧¹; 王宗仁²综述; 李军昌²审校

(第四军医大学：1.2010级硕士研究生管理大队，2.第一附属医院中医科，陕西 西安 710032)

Author(s):

YI Hui¹;  WANG Zong-ren²;  LI Jun-chang²

(1.Brigade of Postgraduates, 2.Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)

关键词:

促血管生成素; 血管内皮生长因子; 血管新生; 血管成熟

Keywords:

angiopoietin;  VEGF;  angiogenesis;  vascular maturation

分类号:

R331.32

DOI:

-

文献标识码:

A

摘要:

血管的新生和成熟需要经过血管内皮细胞与血管周围细胞间相互作用等一系列复杂的生物学过程，这一过程受到多种细胞因子的调控。促血管生成素(angiopoietin，Ang)是近年发现的一个与血管新生与成熟密切相关的家族，包括4个成员，即Ang1、Ang2、Ang3和Ang4，其共同的特异性受体为Tie2。Ang及受体Tie2在生理性血管形成过程中对新生血管的形成、重构及成熟发挥重要的调控作用。另有研究显示，Ang/Tie2系统也参与了缺血后再灌、肿瘤及视网膜病变等多种病理性血管的形成过程。研究Ang/Tie2系统的生物学效应以及其在血管新生与成熟过程中的表达及意义，有助于深入了解相关疾病的发病机制并为疾病的治疗提供新线索。

Abstract:

Angiogenesis and vascular maturation require a complicated biological process through the interactions between vascular endothelial cells and mural cells. The process is affected by many types of cell factors. Recent studies have found that angiopoietin is a system that has a close relationship with neovascularization and vascular maturation. The system includes four members, namely, Ang1, Ang2, Ang3 and Ang4, and their common receptor with specificity is Tie2. Ang and its receptor Tie 2 system are two significant factors in regulating the integrity of vessels in the process of physiological and pathological generation of vessels. Ang and Tie2 system play an important role in the formation of pathological vessels such as in the process of vasoganglion growth, recirculation after ischemia, tumor and retinopathy.

参考文献/References

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备注/Memo

备注/Memo:

收稿日期：2011-12-19.基金项目：国家自然科学基金项目资助（81072972） 通讯作者：李军昌，副教授，主要从事中西医结合心血管病的研究Email:lijunch@fmmu.edu.cn 作者简介：衣慧，硕士生Email:wjcyh99@126.com

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更新日期/Last Update: 2012-07-20