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|本期目录/Table of Contents|

糖尿病性心肌病变患者胰岛素强化治疗前后氧化应激水平的变化

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第5期
页码:
606-608
栏目:
临床研究
出版日期:
2012-10-25

文章信息/Info

Title:
Effect of continuous subcutaneous insulin injection on oxidative stress level in patients with diabetic cardiomyopathy
作者:
黄 海1; 宋成运1; 杜大勇1; 马建新1; 李运田1; 张世俊1; 许玉韵2
(1.解放军第305医院心脏病中心，北京 100017；
2.北京大学第一医院心内科，北京 100034)
Author(s):
HUANG Hai1;  SONG Cheng-yun1;  DU Da-yong1;  MA Jian-xin1;  LI Yun-tian1;  ZHANG Shi-jun1;  XU Yu-yun2
(1.Center of Cardiology, PLA 305 Hospital, Beijing 100017, China; 2.Department of Cardiology, First Hospital, Peking University, Beijing 100034, China)
关键词:
心肌病; 糖尿病性; 胰岛素泵; 氧化应激
Keywords:
cardiomyopathy;  diabetic;  insulin pump;  oxidative stress
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
目的:评价糖尿病性心肌病(DCM)患者胰岛素泵强化治疗前后氧化应激水平的变化。方法： 30例DCM患者采用胰岛素泵强化治疗，治疗达标前后进行超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-PX）、丙二醛（MDA）水平测定并进行比较。结果： 胰岛素泵强化治疗后，患者血浆中的SOD、GSH-PX水平明显上升（P<0.01）、MDA水平明显下降（P<0.01）。空腹血糖、餐后2 h血糖、胰岛素抵抗指数、总胆固醇、三酰甘油、低密度脂蛋白、游离脂肪酸明显降低（P<0.05）,胰岛素分泌功能指数明显上升（P<0.05）。结论： DCM患者使用胰岛素泵强化治疗后氧化应激水平明显降低。
Abstract:
AIM:To evaluate the effect of continuous subcutaneous insulin injection on oxidative stress level in patients with diabetic cardiomyopathy (DCM). METHODS: Thirty patients with DCM were treated with continuous subcutaneous insulin injection. SOD, GSH-PX and MDA were compared before and after insulin pump therapy. RESULTS: After treatment, SOD and GSH-PX levels significantly increased, whereas the MDA level significantly decreased (P<0.01). CONCLUSION: Oxidative stress level in DCM patients significantly decreases after continuous subcutaneous insulin injection treatment.

参考文献/References

[1]Brownlee M.The pathobiology of diabetic complications: a unifying mechanism[J].Diabetes,2005,54(6):1615-1625.
[2]Li SY,Yang X,Ceylan-Isik AF,et al.Cardiac contractile dysfunction in Lep/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca2+-ATPase and myosin heavy chain isozyme switch[J]. Diabetologia,2006,49(6):1434-1446.
[3]侯伊玲,陈彦婷,王淑萍,等.糖尿病心肌病发病机制研究进展[J].武警医学院学报,2007,16(6):688.
[4]Rubler S,Dlugash J,Yuceoglu YZ,et al.New type of cardiomyopathy associated with diabetic glomerolosclerosis[J].Am J Cardiol,1972,30(6):595-602.
[5]Zhou GH,Li XK,Hein DW,et al.Metallothionein suppresses angiotensin Ⅱinduced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart[J].J Am Coll Cardiol,2008,52(8):655-666.
[6]黄 海,祝开思,王平,等.新诊断的2型糖尿病患者胰岛素强化治疗前后氧化应激水平的变化[J].中国糖尿病杂志,2011,19(5):338-339.

备注/Memo

备注/Memo:
收稿日期：2012-04-09.
作者简介：黄海，主治医师，硕士Email:hhbrood@hotmail.com
更新日期/Last Update: 2012-11-16