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|本期目录/Table of Contents|

迷走神经在心律失常发生中的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第5期
页码:
646-650
栏目:
综述
出版日期:
2012-10-25

文章信息/Info

Title:
Role of vagal nerve in cardiac arrhythmia
作者:
冯 璇; 臧伟进; 周 筠
(西安交通大学医学院药理学系，陕西 西安 710061)
Author(s):
FENG Xuan;  ZANG Wei-jin;  ZHOU Jun
(Department of Pharmacology, College of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China)
关键词:
长QT综合征; 迷走神经; 心律失常
Keywords:
Long QT syndrome;  vagal nerve;  cardiac arrhythmia
分类号:
R541.7
DOI:
-
文献标识码:
A
摘要:
作为遗传性心律失常之一的长QT综合征（LQTS），现已发现有12型，其中在中国以LQT2为常见，可诱发尖端扭转型室性心动过速及室颤，临床上以反复发作的晕厥及常导致的猝死为特征。自主神经通过释放神经递质作用于受体调节离子通道，从而对某些心律失常起到一定的作用，而迷走神经通过直接或间接作用对多种心律失常具有一定的保护作用。本文主要对LQT2的研究进展、迷走神经与LQT2的关系以及其在心律失常中发挥的作用作一综述。
Abstract:
As one of the familial abnormalities of cardiac rhythm, Long QT syndrome (LQTS) has been found in 12 different genes. LQT2 is one of the most common LQTS in China, which can lead to Torsade de Points (TdP) and ventricular fibrillation (VF). Clinically it is characterized by recurrent syncope and sudden cardiac death. The autonomic nervous system plays a vital role in some cases of cardiac arrhythmia through the release of neurotransmitter to regulate ion channel. Recently, studies have shown that vagal nerve can reduce the occurrence of certain kinds of cardiac arrhythmia and may play an important role in maintaining normal cardiac rhythm and rate. This paper mainly reviews the recent advances of LQT2, the complex relationship between vagal nerve and LQT2, and the role of vagal nerve in cardiac arrhythmia.

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备注/Memo

备注/Memo:
收稿日期：2012-04-21.
基金项目：国家自然科学基金项目资助（30930105，81170176）； 西安交通大学自主创新项目资助（XJJ20100036）
通讯作者：周筠，副教授，主要从事心血管药理学研究Email:jzhou829@yahoo.com.cn
作者简介：冯璇，硕士生Email:fengxuan0723@163.com
更新日期/Last Update: 2012-11-16