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|本期目录/Table of Contents|

自噬在常见心血管疾病中的作用

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第5期
页码:
655-657
栏目:
综述
出版日期:
2012-10-25

文章信息/Info

Title:
The role of autophagy in common cardiovascular disease
作者:
唐淑丽; 朱敏玲 综述; 尹新华 审阅
(哈尔滨医科大学附属第一医院心血管内科，黑龙江 哈尔滨 150001)
Author(s):
TANG Shu-li;  ZHU Min-ling;  YIN Xin-hua
(Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China)
关键词:
自噬; 心肌细胞; 心肌肥厚; 心室重构; 心肌缺血/再灌注损伤
Keywords:
autophagy;  cardiocyte;  cardiac hypertrophy;  ventricular remodeling;  ischemia/reperfusion
分类号:
R392.3
DOI:
-
文献标识码:
A
摘要:
自噬是细胞利用细胞内溶酶体清除过量或受损的长半衰期蛋白质及细胞器的现象。自噬可通过营养剥夺适应，清除细胞内蛋白质及微细胞器等生理及病理学作用和再利用细胞废物，以维持内环境稳定、参与生长发育和疾病的发生及发展。研究发现，自噬参与了心肌肥厚、心室重构、心肌缺血/再灌注损伤等多种心血管疾病病的理生理过程。本文主要阐述自噬在正常心脏及各种常见心脏疾病中作用的研究进展，并初步探讨可能的治疗新靶点。
Abstract:
Autophagy is a phenomenon in which the cell degrades its own components such as bulk impaired long-lived proteins and organelles. It is a lysosomal degradation pathway essential for survival, differentiation, development and homeostasis. Recent studies have demonstrated a variety of physiological and pathophysiological roles in autophagy, for example, adaptation to nutrient deprivation and intracellular clearance of protein and organelles. Autophagy plays an important pathophysiological role in cardiovascular diseases including cardiac hypertrophy, ventricular remodeling and ischemia/reperfusion. In this review we will summarize the effects of autophagy in normal heart and cardiovascular diseases and probe into possible new therapeutic targets.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2012-04-01.
基金项目：高等学校博士学科点专项研究基金项目资助 （200802260006）；国家自然科学基金项目资助（30872387）
通讯作者：尹新华，教授，主要从事免疫抑制剂引起的心肌损伤研究Email：harbin0910@yahoo.com
作者简介：唐淑丽，硕士生Email：tangshuli2005@163.com
更新日期/Last Update: 2012-11-16