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|本期目录/Table of Contents|

在糖尿病和糖代谢异常/糖耐量异常患者中辛伐他汀治疗对血循环白细胞计数的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第6期
页码:
746-748
栏目:
临床研究
出版日期:
2012-12-25

文章信息/Info

Title:
Association of circulating leukocyte count with diabetes mellitus and impaired fasting glucose/impaired glucose tolerance regression after simvastatin treatment
作者:
杨 文; 于晓红; 常 艳; 王玉柱; 张春燕
(北京海军总医院干二科，北京 100048)
Author(s):
YANG Wen;  YU Xiao-hong;  CHANG Yan;  WANG Yu-zhu;  ZHANG Chun-yan
(Second Department of Geriatrics, Navy General Hospital, Beijing 100048, China)
关键词:
白细胞计数; 糖尿病; 辛伐他汀
Keywords:
peripheral blood leukocyte count;  simvastatin;  diabetes mellitus
分类号:
R587.1;R972.6
DOI:
-
文献标识码:
A
摘要:
目的:观察应用辛伐他汀是否可以降低糖尿病和糖代谢异常(IFG)/糖耐量异常（IGT)患者血循环中白细胞计数(WBC)。方法： 糖尿病患者(n=57)、IFG/IGT患者(n=42)和对照组(n=44),服用辛伐他汀(20 mg/d) 6个月。3组患者均进行正常的体力活动，分别于治疗前和治疗6月后清晨空腹抽血测定白细胞计数、血浆总胆固醇(TC)和三酰甘油(TG)，并统计其服药前后血压变化的情况。结果： 糖尿病患者、IFG/IGT患者治疗后血循环中白细胞计数和中性粒细胞百分比显著减少(P<0.01,P<0.05)，TG和TC在糖尿病、IFG/IGT组和正常对照组治疗后均明显降低(P<0.01或P<0.05)。结论： 辛伐他汀可以明显降低糖尿病和IFG/IGT患者血循环中的WBC、中性粒细胞百分比。
Abstract:
AIM:To investigate the effects of simvastatin on the levels of peripheral blood leukocyte count, serum total cholesterol and triglycerides in patients with diabetes mellitus and impaired fasting glucose/impaired glucose tolerance (IFG/IGT). METHODS: Diabetes mellitus patients ［n=57, 48 males, average age (74±9) years］, IFG/IGT patients ［n=42, 35 males, average age (73±6) years］ and controls ［n=44, 37 males, average age (74±7) years］ were subjected to simvastatin treatment (20 mg/day) for 6 months. Patients in all three groups performed normal physical activity and plasma samples were collected after overnight fasting at baseline before and after the 6-month treatment for examination. RESULTS: Simvastatin treatment significantly reduced the peripheral blood leukocyte count and percentage of neutrophils in IFG/IGT and patients with diabetes mellitus (P<0.01, P<0.05). Post-treatment levels of plasma triglycerides were significantly lower than those pre-treatment in patients with diabetes mellitus and IFG/IGT (P<0.01). Post-treatment levels of total plasma cholesterol were significantly lower compared with those pre-treatment in all three groups (P<0.01, P<0.05). CONCLUSION: Simvastatin markedly lowered peripheral blood leukocyte count and plasma triglyceride levels and the percentage of neutrophils in patients with diabetes mellitus and IFG/IGT. Statin-induced inhibition of peripheral blood leukocyte count may play an important role in the pharmacological treatment of cardiovascular diseases.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2012-04-01.作者简介：杨文，副主任医师，硕士 Email:yangwen666123@sohu.com
更新日期/Last Update: 2012-12-30