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|本期目录/Table of Contents|

镁合金可降解的肝素及bFGF支架在心肌血运重建中的应用研究

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2013年第2期
页码:
168-171
栏目:
基础研究
出版日期:
2013-04-25

文章信息/Info

Title:
Experimental study of degradable magnesium alloy stent with heparin and basic fibroblast growth factor in myocardial revascularization after acute myocardial infarction
作者:
杨 力; 张杰民; 刘晓程; 王永旺
(中国医学科学院北京协和医学院泰达国际心血管病医院心脏外科，天津 300457)
Author(s):
YANG Li;  ZHANG Jie-min;  LIU Xiao-cheng;  WANG Yong-wang
(Department of Cardiology Surgery, TEDA International Cardiovascular Hospital, CAMS and PUMC, Tianjin 300457, China)
关键词:
心肌梗死; 心肌血运重建; 肝素; 碱性成纤维细胞生长因子; 支架; 猪
Keywords:
myocardial infarction;  myocardial revascularization;  heparin;  basic fibroblast growth factor;  stent;  swine
分类号:
R542.22
DOI:
-
文献标识码:
A
摘要:
目的:探讨镁合金可降解联合肝素及碱性成纤维细胞生长因子(bFGF)支架改善心肌缺血区灌注情况。方法： 对18只小猪通过结扎前降支冠状动脉建立急性心肌梗死模型，然后随机分为3组(每组6只)，A组为对照组，B组为心肌打孔+镁合金复合缓释肝素可降解支架植入组，C组为心肌打孔+镁合金可降解复合缓释肝素和bFGF支架植入组。在B和C组中，于心肌梗死区采用自制高速钻孔器由心外膜打两个直径为2 mm的透壁孔道，每个孔道内植入1枚支架。6周后，用Image Pro Plus 6.0软件量化各组新生血管的密度。于治疗前和治疗后6周，用SPECT结合软件Emory Cardiac Toolbox分析心肌灌注缺损区域质量百分率，超声学指标左室舒张末直径(LVEDD)、右室收缩末直径(LVESD)、左心室射血分数(LVEF)评价心脏的功能。结果： 治疗后6周，B组和C组LVEF及心肌灌注质量缺损较A组明显改善（P<0.05）；C组中新生血管密度百分率较A组和B组显著改善（P<0.01）。结论： 镁合金复合肝素及bFGF可降解支架能够显著增加缺血心肌新生血管的密度，改善缺血部位心肌的血流灌注，进而提高心脏功能。
Abstract:
AIM:To investigate the effects of degradable magnesium alloy stent with heparin and basic fibroblast growth factor (bFGF) implanted into transmural channels on myocardial revascularization after acute myocardial infarction. METHODS: Eighteen mini-swines were used to comprise the animal model by ligating the middle third of the left anterior descending (LAD). Animals were randomly divided into three groups: control group (A group, n=6), transmyocardial drilling revascularization (TMDR)+magnesium alloy stent with heparin group (B group, n=6) and TMDR+magnesium alloy stent with heparin and bFGF implantation group (C group, n=6). In groups B and C, two 2-mm diameter transmural channels were established using a self-made drilling device, followed by implantation of two stents into the channels in the two groups. Quantitative analysis of new vessels was performed by Image Pro Plus software 6 weeks postoperatively. The mass defect percent of myocardial perfusion was calculated by Emory Cardiac Toolbox software, and LVEDD, LVESD and LVEF reflective of cardiac functions were measured by echocardiology at pre-treatment and 6 weeks post-treatment. RESULTS: Six weeks postoperatively, both LVEF and mass defect percent in B group and C group showed significant differences compared with those in A group (P<0.05). New vessel density significantly increased in C group compared with that in A and B groups (P<0.01). CONCLUSION: Degradable magnesium alloy stent with heparin and bFGF increases new vessel density and improves myocardial perfusion, thus enhancing cardiac functions.

参考文献/References

[1]Mukherjee D,Bhatt DL,Roe MT,et al.Direct myocardial revascularization and angiogenesis-how many patients might be eligible?[J].Am J Cardiol,1999,84(5):598-600,A8.
[2]Wang Y,Liu XC,Zhang GW,et al.A new transmyocardial degradable stent combined with growth factor, heparin, and stem cells in acute myocardial infarction[J].Cardiovasc Res,2009,84(3):461-469.
[3]Liu XC,Zhao J,Wang Y,et al.Heparin- and basic fibroblast growth factor-incorporated stent: a new promising method for myocardial revascularization[J].J Surg Res,2010,164(2):204-213.
[4]Zhang GW,Liu XC,Li-Ling J,et al.Mechanisms of the protective effects of BMSCs promoted by TMDR with heparinized bFGF-incorporated stent in pig model of acute myocardial ischemia[J].J Cell Mol Med,2011,15(5):1075-1086.
[5]Sen PK,Udwadia TE,Kinare SG,et al.Transmyocardial acupuncture, a new approach to myocardial revascularization[J].J Thorac Cardiaovasc Surg,1965,50(2):181-189.
[6]Chang PY, Lu SC,Lee CM,et al.Homocysteine inhibits arterial endoliethial cell growth through transcriptional downregulation of fibroblast growth factor-2 involving G protein and DNA methylation[J].Circ Res,2008,102(8):933-941.
[7]Iwakura A,Fujita M,Kataoka K,et al.Intramyocardial sustained delivery of basic fibroblast growth factor improves angiogenesis and ventricular function in a rat infacrtion model[J].Heart Vessels,2003,18(4):93-99.

备注/Memo

备注/Memo:
收稿日期：2012-08-13.通讯作者：刘晓程，教授，主要从事冠心病心肌血运重建的研究Email:liuxc1949@hotmail.com 作者简介：杨力,主治医师,博士 Email:jeffrey801011@yahoo.com.cn
更新日期/Last Update: 2013-04-28