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|本期目录/Table of Contents|

激动κ-阿片受体通过抑制血管紧张素II/AT1受体途径发挥抗心律失常作用的探讨

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2013年第2期
页码:
230-233
栏目:
综述
出版日期:
2013-04-25

文章信息/Info

Title:
κ-Opioid receptor stimulation exerts antiarrhythmic effects through negative regulation of angiotensin II/AT1 receptor pathway
作者:
郑煦暘1; 赵施皓1; 杨智伟1; 张淑苗2; 李 娟2; 冯 娜2; 裴建明2
(第四军医大学：1.口腔医学系3队，2.基础部生理学教研室，陕西 西安 710032)
Author(s):
ZHENG Xu-yang1;  ZHAO Shi-hao1;  YANG Zhi-wei1;  Zhang Shu-miao2;  LI Juan2;  FENG Na2;  PEI Jian-ming2
(1.Team 3, School of Stomatology, 2.Department of Physiology, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
κ阿片受体; 血管紧张素II; 心律失常
Keywords:
angiotensin II;  κ-opioid receptor;  arrhythmia
分类号:
R971.2；R541.7
DOI:
-
文献标识码:
A
摘要:
阿片样物质/κ阿片受体（κ-opioid receptor,κ-OR）途径和血管紧张素II（angiotensin II,AngII）/AT1受体途径都是调节心血管系统功能的重要信号通路。多年以来，人们对激动κ-OR的心肌保护效应和激活AngII/AT1受体途径促进心律失常发生和发展的作用分别进行了许多研究，但激动κ-OR是否可通过负性调节AngII/AT1受体途径来发挥抗心律失常作用的问题迄今仍缺乏探索。本文在总结以往对以上两途径研究成果的基础上，探讨了激动κ-OR通过对AngII/AT1受体途径的负性调节从而发挥抗心律失常的作用，可望为心律失常的防治提供新的研究思路。
Abstract:
Both opioid/κ-opioid receptor (κ-OR) pathway and angiotensin II (AngII)/AT1 receptor pathway are important pathways regulating the functions of the cardiovascular system. Although the myocardial protective function of κ-OR stimulation and the arrhythmic effect of AngII have been extensively investigated, whether the stimulation of κ-OR exerts antiarrhythmic effects through negative regulation of the Ang II/AT1 receptor pathway is still unclear. This review discusses the antiarrhythmic effect of κ-OR stimulation through negative regulation of AngII/AT1 receptor pathway and provides new insight into the prevention and treatment of arrhythmic diseases.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2012-09-19.基金项目：国家自然科学基金项目资助（30900535,30971060,31100827,81270402,31200875）；陕西省自然科学基金项目资助（ 2010K01195，2011JM4001）;陕西省科学技术研究发展计划项目资助(S2010SF883) 通讯作者：裴建明，教授，主要从事κ阿片受体介导心脏保护研究 Email:jmpei8@fmmu.edu.cn 作者简介：郑煦暘，本科生Email：zhengxuyang123456@126.com 共同第一作者：赵施皓，本科生 Email：765595720@qq.com
更新日期/Last Update: 2013-04-28