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|本期目录/Table of Contents|

钙敏感受体参与低氧性肺动脉高压形成的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2013年第4期
页码:
490-493
栏目:
综述
出版日期:
2013-07-25

文章信息/Info

Title:
Advances of study on involvement of calcium sensing receptor in the formation of hypoxic pulmonary hypertension
作者:
杨智伟1; 赵施皓1; 郑煦暘1; 李 娟2; 裴建明2
（第四军医大学：1.口腔医学系3队，2.基础部生理学教研室，陕西 西安 710032）
Author(s):
YANG Zhi-wei1;  ZHAO Shi-hao1;  ZHENG Xu-yang1;  LI Juan2;  PEI Jian-ming2
(1.Team 3, Faculty of Stomatology, 2.Department of Physiology, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
钙敏感受体; 肺动脉; 低氧性肺动脉高压; 钙离子
Keywords:
calcium sensing receptor;  pulmonary artery;  hypoxic pulmonary hypertension;  calcium
分类号:
R971.1；R543.2
DOI:
-
文献标识码:
A
摘要:
低氧性肺动脉高压（hypoxic pulmonary hypertension，HPH）的发病机制目前还不十分清楚。近年来越来越多的研究发现，钙敏感受体（calcium sensing receptor，CaSR）参与了HPH的发生和发展。研究表明，肺动脉平滑肌细胞（pulmonary artery smooth muscle cells，PASMCs）可表达CaSR，CaSR对PASMCs中钙浓度的变化、肺血管紧张度的调节与PASMCs增殖发挥着重要作用，因此，CaSR的研究可为阐明HPH发病机制提供一个新的方向，本文简要介绍了CaSR参与HPH形成的研究进展。
Abstract:
The mechanism underlying the formation of hypoxic pulmomary hypertension (HPH) is still unclear at present, more and more research indicated that calcium sensing receptor (CaSR) participated in the occurrence and development of HPH. Increasing evidence suggested that CaSR expressed in the pulmonary artery smooth muscle cells (PASMCs) and CaSR played an important role in the regulation of calcium concentration in the PASMCs, the regulation of pulmonary vascular tensity and the control of PASMC proliferation. Therefore, the study on the role of CaSR in HPH might provide a new direction for clarifying the pathogenesis of HPH. This article reviews the involvement of CaSR in the formation of HPH.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2012-09-27.基金项目：国家自然科学基金项目资助（30900535,30971060, 31100827,81270402,31200875）；陕西省自然科学基金项目资助（2010K01195，2011JM4001）;陕西 省科学技术研究发展计划项目资助(S2010SF883) 通讯作者：李娟，讲师，主要从事κ阿片受体介导心肺循环保护研究 Email:lijuan2162008@163.com 作者简介：杨智伟，本科生 Email：502278415@qq.com 共同第一作者：赵施皓，
更新日期/Last Update: 2013-07-29