基质金属蛋白酶9基因-1562位点C>T多态性与冠心病关系的Meta分析
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2013年第5期
- 页码:
- 531-535
- 栏目:
- 临床研究
- 出版日期:
- 2013-09-25
文章信息/Info
- Title:
- Association of -1562C>T polymorphism of matrix metalloproteinase-9 gene and coronary artery disease: a meta-analysis
- Author(s):
- ZHOU Dong1; XIAO Min2; WAN Zhao-fei1; YUAN Zu-yi1
- (1.Department of Cardiovascology, First Affiliated Hospital, Medical School, Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China; 2. Intensive Care Unit, Hanzhong 3201 Hospital, Hanzhong 723000, Shaanxi, China)
- 分类号:
- R541.4
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的:评价基质金属蛋白酶-9基因-1562位点C>T多态性与冠心病的关系。方法： 通过PubMed，Elsevier，EMbase，CNKI等数据库搜索2012年11月30日以前发表的基质金属蛋白酶-9基因-1562位点C>T多态性与冠心病关联性的病例对照研究文章，剔除不符合要求的文献，并根据各入选文献结果的同质性检验结果进行数据合并，计算总OR值，Meta分析采用Revman5.0及Stata11.0统计软件。结果： 共有13篇病例对照研究纳入。Meta分析TT+CT基因型比CC基因型OR=1.29(95%CI为1.13～1.47，P<0.01) ；T等位基因比C等位基因OR=1.27(95%CI为1.13～1.42，P<0.01)；CT基因型比CC+TT基因型OR=1.29（95%CI：1.13～1.48），P<0.01)。结论： 基质金属蛋白酶-9基因1562位点C>T多态性与冠心病发病相关，基质金属蛋白酶-9基因1562位点T等位基因是冠心病易感性的标记基因。
- Abstract:
- AIM:To evaluate the relationship of matrix metalloproteinase-9 gene -1562 C>T polymorphisms with coronary artery disease (CAD). METHODS: A literature search was conducted in PubMed, Elsevier, EMbase, and CNKI database to identify eligible case-control studies published before November 30, 2012 on the relationship between matrix metalloproteinase-9 gene -1562 C>T polymorphism and CAD. The odds ratios of all the studies were combined, dependent on the results of heterogeneity tests among the individual studies. Review Manager (v.5.0) and Stata (v.11.0) were used for meta-analysis. RESULTS: A total of 13 case-control studies were identified. No publication bias was identified in the 13 reviewed studies. The summarized odds ratios of TT and CT genotype combination vs. CC genotype across all 13 studies was OR=1.29 (95%, CI 1.13-1.47, P<0.01), T genotype vs. C genotype was OR=1.27 (95%, CI 1.13-1.42, P<0.01), and CT genotype vs. CC and TT genotype combination was OR=1.29 (95%, CI 1.13-1.48, P<0.01). CONCLUSION: C>T polymorphism of the matrix metalloproteinase-9 gene -1562 is associated with CAD. T allele of matrix metalloproteinase-9 gene may be the susceptibility marker for CAD.
参考文献/References
[1]Kim JS,Park HY,Kwon JH,et al.The roles of stromelysin-1 and the gelatinase B gene polymorphism in stable angina[J].Yonsei Med J,2002,43(4):473-481.
[2]Morgan AR,Zhang B,Tapper W,et al.Haplotypic analysis of the MMP-9 gene in relation to coronary artery disease[J].J Mol Med(Berl),2003,81(5):321-326.
[3]孟冬梅,毛用敏,陈 倩,等.基质金属蛋白酶基因多态性与冠心病的关系[J].天津医药,2006,34(5):295-298.
[4]Nuzzo D,Vasto S,Balistreri CR,et al.Role of proinflammatory alleles in longevity and atherosclerosis:results of studies performed on -1562C/T MMP-9 in centenarians and myocardial infarction patients from Sicily[J].Ann N Y Acad Sci,2006,1089:496-501.
[5]陈白玉,李熙芹,何汉江,等.急性冠状动脉综合征患者基质金属蛋白酶9 基因多态性[J].中国动脉硬化杂志,2007,15(3):209-212.
[6]王梅芳,肖传实,巩书文,等.基质金属蛋白酶-9C-1562T基因多态性与冠心病相关关系的初步研究[J].临床血液学杂志,2007,20(1):28-30.
[7]Nanni S,Melandri G,Hanemaaijer R,et al.Matrix metalloproteinases in premature coronary atherosclerosis: influence of inhibitors,inflammation, and genetic polymorphisms[J].Transl Res, 2007, 149(3):137-144.
[8]Wang L,Zhu T,Li Y,et al.Relationship between matrix metaloproteinase-9 polymorphism and acute coronary syndrome[J].Journal of Nanjing Medical University,2007,21(3):147-150.
[9]张 岩,王聪霞,董 新,等.基质金属蛋白酶2，9 基因多态性与早发冠心病遗传易感性的研究[J].西安交通大学学报（医学版）,2008,31(4):429-433.
[10]Koh YS,Chang K,Kim PJ,et al.A close relationship between functional polymorphism in the promoter region of matrix metalloproteinase-9 and acute myocardial infarction[J].Int J Cardiol,2008,127(3):430-432.
[11]Alp E,Menevse S,Tulmac M,et al.Lack of association between matrix metalloproteinase-9 and endothelial nitric oxide synthase gene polymorphisms and coronary artery disease in Turkish population[J].DNA Cell Biol,2009,28(7):343-350.[12]Zhi H,Wang H,Ren L,et al.Functional polymorphisms of matrix metallopeptidase-9 and risk of coronary artery disease in a Chinese population[J].Mol Biol Rep,2010,37(1):13-20.
[13]Opstad TB,Pettersen AA,Weiss TW,et al.Genetic variation,gene-expression and circulating levels of matrix metalloproteinase-9 in patients with stable coronary artery disease[J].Clin Chim Acta,2012,413(1-2):113-120.
[14]Saedi M,Vaisi-Raygani A,Khaghani S,et al.Matrix metalloproteinase-9 functional promoter polymorphism 1562C>T increased risk of early-onset coronary artery disease[J].Mol Biol Rep,2012,39(1):555-562.
[15]Pollanen PJ,Karhunen PJ,Mikkelsson J, et al. Coronary artery complicated lesion area is related to functional polymorphism of matrix metalloproteinase 9 gene: an autopsy study[J].Arterioscler Thromb Vasc Biol,2001,21(9):1446-1450.
[16]Tretjakovs P,Jurka A,Bormane I,et al.Circulating adhesion molecules, matrix metalloproteinase-9,plasminogen activator inhibitor-1, and myeloperoxidase in coronary artery disease patients with stable and unstable angina[J].Clin Chim Acta,2012,413(1):25-29.
[17]Wang LX,Lü SZ,Zhang WJ,et al.Comparision of high sensitivity C-reactive protein and matrix metalloproteinase 9 in patients with unstable angina between with and without significant coronary artery plaques[J].Chin Med J (Engl),2011,124(11):1657-1661.
[18]Kobayashi N,Hata N,Kume N,et al.Matrix metalloproteinase-9 for the earliest stage acute coronary syndrome[J].Circ J,2011,75(12):2853-2861.
[19]Shevchenko AV,Golovanova OV,Konenkov VI,et al.Analysis of the gene polymorphism of matrix metalloproteinase-2 and -9 in patients with coronary heart disease[J].Ter Arkh, 2010, 82(1):31-34.
[20]Eldrup N,Kragelund C,Steffensen R,et al.Prognosis by C-reactive protein and matrix metallo proteinase9 levels in stable coronary heart disease during 15 years of followup[J].Nutr Metab Cardiovasc Dis,2012,22(8):677-683.
备注/Memo
- 备注/Memo:
- 收稿日期：2013-03-12.通讯作者：袁祖贻，教授，主要从事冠心病、动脉粥样硬化的发生机制研究 Email：zuyiyuan@mail.xjtu.edu.cn 作者简介：周栋，博士生 Email：zhoudong8587@126.com
常用功能
统计/Statistics
- 摘要浏览/Viewed1047
- 评论/Comments
