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|本期目录/Table of Contents|

维生素D缺乏与高血压病患者血清NTproBNP浓度的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2013年第5期
页码:
540-542
栏目:
临床研究
出版日期:
2013-09-25

文章信息/Info

Title:
Relationship between vitamin D deficiency and serum NTprobrain natriuretic peptide concentration in patients with hypertension
作者:
金丹玲; 刘兆军
(沈阳市第五人民医院心内二科，辽宁 沈阳 110023)
Author(s):
JIN Dan ling;  LIU Zhao jun
(Second Department of Cardiology, Shenyang Fifth People’s Hospital, Shenyang 110023, Liaoning, China)
关键词:
维生素D; 高血压; 原发性; 脑钠尿肽原; 心力衰竭
Keywords:
vitamin D;  hypertensive disease;  NTprobrain natriuretic peptide;  heart failure
分类号:
R541.6
DOI:
-
文献标识码:
A
摘要:
目的:研究高血压病患者中维生素D的缺乏与血清N末端脑钠尿肽原（NT-pro-BNP）浓度的关系。方法：选取2009年～2012年住院高血压病患者，根据血清25-羟维生素D［25(OH)D］浓度由高到低将入选患者分为4组：A组：对照组25(OH)D浓度≥30 ng/ml；B组:20 ng/ml<25(OH)D浓度<30 ng/ml；C组:10 ng/ml<25(OH)D浓度<20 ng/ml；D组:25(OH)D浓度≤10 ng/ml，测定血清NT-pro-BNP浓度，并作受试者血清各指标与血清NT-pro-BNP浓度相关性的分析。结果： B组和C组血清NT-pro-BNP浓度较对照组没有显著性差异。D组血清NT-pro-BNP浓度较对照组明显升高，差异有统计学意义（P<0.05），D组血清NT-pro-BNP浓度较C组升高，差异有统计学意义（P<0.05），即随着血清25(OH)D浓度的降低其血清NTproBNP浓度显著升高。受试者血糖、血钙、总胆固醇、三酰甘油、糖化血红蛋白（HbA1C）、同型半胱氨酸、肌酐、甲状旁腺素与血清NTpro-BNP浓度没有相关性。结论：维生素D的缺乏明显增加高血压病患者发生心力衰竭的风险。
Abstract:
AIM:To study the relationship between vitamin D deficiency and serum NT-pro-brain natriuretic peptide in hypertensive patients. METHODS: On the basis of the plasma levels of 25(OH)D, hypertensive patients in our hospital from 2009 to 2012 were divided into four groups: control group with 25(OH)D density≥30 ng/ml, group B with 20 ng/ml<25(OH)D density<30 ng/ml, group C with 10 ng/ml<25(OH)D density<20 ng/ml and group D with 25(OH)D density≤10 ng/ml. Serum NT-pro-brain natriuretic peptide concentration was evaluated and the correlation between serum indexes and serum NT-pro-brain natriuretic peptide concentration was analyzed. RESULTS: A total of 150 hypertensive patients aged 30-85 years were included in the study. No significant difference was found in the serum NT-pro-brain natriuretic peptide concentration between groups B and C and control group (95%CI: -38.63-195.92, P>0.05; 95%CI: 84.44-311.25, P>0.05). Serum NT-pro-brain natriuretic peptide concentration in group D was significantly higher than in control group (95%CI: 181.42-409.99, P<0.05) and was significantly higher than in group C. Serum NTprobrain natriuretic peptide concentration in each group markedly increased with the decrease of plasma levels of 25(OH)D. No correlation was found between the serum NTprobrain natriuretic peptide concentration and serum indexes including blood sugar, blood calcium, total cholesterol, triglyceride, homocysteine, creatinine and parathormone. CONCLUSION: Vitamin D deficiency obviously enhances the risk of heart failure in hypertensive patients.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2013-03-31.作者简介：金丹玲，主治医师，硕士 Email;jindanling@126.com
更新日期/Last Update: 2013-09-30