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降纤酶对非ST段抬高型心肌梗死患者TNF-α、hs-CRP水平的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2013年第6期
页码:
665-667
栏目:
临床研究
出版日期:
2013-11-25

文章信息/Info

Title:
Impact of defibrase on hsCRP and TNF-α in patients with nonST segment elevation myocardial infarction
作者:
刘 欣; 邬德朔; 侯贺功
(巨野县人民医院心内二科， 山东 巨野 274900)
Author(s):
LIU Xin;  WU De shuo;  HOU He gong
(Department of Cardiology, People’s Hospital of Juye County, Juye 274900, Shandong, China)
关键词:
非ST段抬高心肌梗死; 高敏C反应蛋白; 肿瘤坏死因子-α; 心室重构
Keywords:
nonST segment myocardial infarction;  ventricular remodeling;  highsensitivity Creactive protein;  tumor necrosis factorα;  defibrase
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:探讨非ST段抬高型心肌梗死（NSTEMI）患者在规范化治疗方案的基础上加用降纤酶后，对其血浆肿瘤坏死因子-α（TNF-α）、血清高敏C反应蛋白（hs-CRP）水平的影响。方法:选取我院住院的急性NSTEMI患者86例，随机分为对照组和试药组，试药组在规范化治疗方案的基础上加用降纤酶，釆用ELISA法检测血浆TNF-α浓度、胶乳增强免疫比浊法测定血清hs-CRP浓度，并评估降纤酶临床疗效。结果:试药组患者血浆TNF-α、血清hs-CRP浓度水平显著降低（均P<0.05）；试药组患者临床总有效率与对照组相比差异未达显著水平，但有明显增高趋势。结论:NSTEMI患者在规范治疗的基础上加用降纤酶后可以有效降低炎症反应指标TNF-α、hs-CRP的浓度水平。
Abstract:
AIM:To probe the impact of defibrase on hsCRP and TNFα in patients with nonST segment myocardial infarction (NSTEMI). METHODS: Eightysix patients with NSTEMI were randomly divided into two groups: control group and treatment group. Standardized treatment was given to the two groups and defibrase was added in the treatment group. ELISA was used to analyze plasma TNFα level and LaTeX enhanced immune turbidimetry method was employed to detect hsCRP. RESULTS: Both TNFα level and hsCRP level significantly decreased in the treatment group compared with the control group (P<0.05). There was no significant difference in the total efficiency rate between the treatment group and control group, but there was an obvious increasing tendency. CONCLUSION: On the basis of standardized treatment, defibrase decreases the levels of inflammation index (TNF-α and hsCRP) in patients with NSTEMI.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2013-03-22.作者简介：刘欣,主治医师，硕士Email：juyeliuxin@outlook.com
更新日期/Last Update: 2013-11-20