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|本期目录/Table of Contents|

Down综合征并发先天性心脏病的临床分析

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第1期
页码:
43-45055
栏目:
临床研究
出版日期:
2013-12-02

文章信息/Info

Title:
Clinical analysis of Down syndrome with congenital heart diseases
作者:
王琦光; 朱鲜阳; 韩秀敏; 张端珍; 崔春生; 陈火元; 肖家旺
(沈阳军区总医院先心病内科，辽宁 沈阳 110016)
Author(s):
WANG Qi-guang;  ZHU Xian-yang;  HAN Xiu-min;  ZHANG Duan-zhen;  CUI Chun-sheng;  CHEN Huo-yuan;  XIAO Jia-wang
(Department of Congenital Heart Disease, General Hospital, Shenyang Military Area Command, Shenyang 110016, Liaoning, China)
关键词:
Down综合征; 先天性心脏病; 心脏畸形; 心导管检查; 肺动脉高压
Keywords:
Down syndrome;  congenital heart disease;  cardiac abnormalities;  cardiac catheterization;  pulmonary arterial hypertension
分类号:
R541.1
DOI:
-
文献标识码:
A
摘要:
目的:总结分析Down综合征(Down’s syndrome)并发的先天性心脏病畸形及血流动力学资料。方法:2008年7月~2012年10月，采用经胸二维超声心动图并彩色多普勒显像及右心导管/心血管造影检查方法，诊断36例并发先心病的Down综合征患者，本文通过36例临床资料分析，探讨Down综合征并发的先心病畸形及其血流动力学。结果:36例患者中室间隔缺损（VSD ）10例，房室间隔缺损（AVSD） 6例，动脉导管未闭（PDA） 6例，房间隔缺损（ASD） 2例，ASD+PDA 2例，ASD+VSD 1例，ASD+PDA+VSD 1例，VSD+PDA 4例，PDA+二叶主动脉瓣（BAV）1例，法洛四联症（TOF）2例，TOF+ASD 1例，18例有肺动脉高压者，其中5例为阻力型肺动脉高压。结论:①Down综合征并发的心血管畸形中，以VSD、AVSD和PDA最为常见，并常并发ASD、TOF。②在无肺动脉狭窄的患者中，约50%并发有肺动脉高压。
Abstract:
AIM:To analyze congenital heart deformity and hemodynamic data of Down syndrome. METHODS: Clinical data of Down’s syndrome with congenital heart disease and its hemodynamics were analyzed in 36 patients diagnosed with congenital heart disease patients with Down syndrome by transthoracic two-dimensional echocardiography, color Doppler flow imaging and right heart catheterization or angiocardiography from July 2008 to October 2012. RESULTS: Among the 36 cases, there were ten patients with VSD, six patients with AVSD, six patients with PDA, two patients with ASD, two cases with ASD+PDA, one case with ASD+VSD, one patient with ASD+PDA+VSD, four patients with VSD+PDA, one patient with PDA+BAV, two patients with TOF 2, and once patient with TOF+ASD. Eighteen patients had pulmonary hypertension including five cases of resistant pulmonary arterial hypertension. CONCLUSION: In cardiovascular malformations with Down syndrome, VSD (28%), AVSD (17%) and PDA (17%) are most common and are often associated with ASD or TOF. In patients without pulmonary artery stenosis, about half are complicated with pulmonary artery hypertension.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2013-06-12.通讯作者：朱鲜阳，主任医师，主要从事结构性心脏病影像诊断和介入治疗研究 Email：xyangz@yahoo.com.cn 作者简介：王琦光，副主任医师，博士 Email：wqg1993@163.com
更新日期/Last Update: 2014-01-20