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|本期目录/Table of Contents|

1,6二磷酸果糖对先天性心脏病矫治术后并发脓毒症患儿凝血功能的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第1期
页码:
53-55
栏目:
临床研究
出版日期:
2013-12-02

文章信息/Info

Title:
Effect of fructose 1,6 2-bisphosphate on coagulation function in children with sepsis after open-heart surgery for congenital heart diseases
作者:
柳 梅1; 李艳萍1; 范学朋1; 尚小珂2
(1.武汉市第-医院ICU，湖北 武汉 430000；2.武汉亚洲心脏病医院心外科，湖北 武汉 430022)
Author(s):
LIU Mei1;  LI Yan-ping1;  FAN Xue-peng1;  SHANG Xiao-ke2
(1.ICU Department, Wuhan First Hospital, Wuhan 430000, Hubei, China; 2.Cardiovascular Surgery ICU, Wuhan Asia Heart Hospital, Wuhan 430022, Hubei, China)
关键词:
脓毒症; 凝血功能; 1; 6-二磷酸果糖
Keywords:
sepsis;  coagulation function;  1; 6 2-bisphosphate
分类号:
R541.1
DOI:
-
文献标识码:
A
摘要:
目的:研究1,6二磷酸果糖（FDP）对先天性心脏病矫治术后脓毒症患儿凝血功能的影响。方法:研究对比23例先天性心脏病矫治术后并发脓毒症的患儿,随机分为常规组（n=12）和试药组（n=11），试药组在常规用药基础上加用FDP治疗，常规组在常规用药基础上给予等量生理盐水，比较各组患儿凝血功能的改变和深静脉血栓发生率。结果:常规组的凝血酶原时间、活化部分凝血活酶时间明显高于试药组（P<0.05），试药组血小板计数明显高于常规组(P<0.05)。D-二聚体、纤维蛋白原无统计学差异。试药组无一例出现深静脉血栓，常规组有1例出现双侧颈内静脉、单侧股静脉血栓。结论:FDP能改善脓毒症患儿的凝血功能。
Abstract:
AIM:To study the effect of fructose 1,6 2-bisphosphate on coagulation function in children with sepsis after open-heart surgery for congenital heart diseases. METHODS: Twenty-three children with sepsis and 26 children without infection (contrast group) after open-heart surgery for congenital heart diseases were included in this study. The 23 children with sepsis were randomly divided into conventional group (n=12) and medication group (n=11). Children in the medication group were treated with 1,6 2-bisphosphate based on routine medication, whereas children in the conventional group were given saline instead of 1,6 2-bisphosphate based on routine medication. No treatment was given in the contrast group. The coagulation function including PT, APTT, Fib and PLT, D-dimer and the incidence rate of deep vein thrombosis were compared among the three groups. RESULTS: PT and APTT in conventional group were obviously higher than those in the contrast group and medication group (P<0.05). PLT level in the medication group was obviously higher than in the conventional group. No statistical difference was observed in D-dimer and Fib. There was one case of deep vein thrombosis in bilateral internal jugular veins and right femoral veins in conventional group and no occurrence of deep vein thrombosis in medication group. CONCLUSION: 1,6 2-bisphosphate improves coagulation function in children with sepsis and reduces the incidence rate of deep vein thrombosis.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2013-05-30.通讯作者：李艳萍，主治医师，主要从事儿科的诊治研究 Email：66799073@qq.com 作者简介：柳梅，硕士生 Email：66799073@qq.com
更新日期/Last Update: 2014-01-20