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|本期目录/Table of Contents|

门冬氨酸钾镁在预防不停跳冠状动脉旁路移植术后心房纤颤发生的作用

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第1期
页码:
67-69
栏目:
临床研究
出版日期:
2013-12-02

文章信息/Info

Title:
Role of potassium magnesium aspartate in preventing postoperative atrial fibrillation after off-pump coronary artery bypass surgery
作者:
郭海平; 赵成秀; 靳振生; 李锐; 郭建英; 李文娟; 杨 健
(邯郸市第一医院心脏外科，河北 邯郸 056002)
Author(s):
GUO Hai-ping;  ZHAO Cheng-xiu;  JIN Zhen-sheng;  LI Rui;  GUO Jian-ying;  LI Wen-juan;  YANG Jian
(Department of Cardiac Surgery, Handen First Hospital, Handan 056002, Hebei, China)
关键词:
门冬氨酸钾镁; 心房纤颤; 不停跳冠状动脉旁路移植术
Keywords:
potassium magnesium aspartate;  atrial fibrillation;  off-pump coronary artery bypass graft
分类号:
R541.7
DOI:
-
文献标识码:
A
摘要:
目的:观察门冬氨酸钾镁在预防不停跳冠状动脉旁路移植（OPCABG）术后心房纤颤发生的作用。方法:所有入选160例患者均第1次接受OPCABG，且术前均为窦性心律。将患者随机分为试药组和对照组（每组80例）。试药组为术后3 d每天静脉内输注门冬氨酸钾镁4 g，对照组术后3 d每天输注安慰剂。排除标准：过去存在房颤病史，安装过心脏起搏器，术后心肌梗死，术中改为停跳搭桥的患者，肾功能不全患者。研究终点是术后发生房颤。结果:试药组房颤发生率为9%，对照组房颤发生率为19%，显著高于试药组（P<0.01）。试药组ICU停留时间显著短于对照组［(2.6±1.3) d vs.(3.6±1.2) d,P<0.05］。结论:术后连续3 d应用门冬氨酸钾镁可以安全有效减少OPCABG术后房颤的发生率。
Abstract:
AIM:To study the role of 3 days of potassium magnessium aspartate after off-pump coronary artery bypass graft (OPCABG) surgery in preventing postoperative atrial fibrillation (AF). METHODS: One hundred sixty patients undergoing isolated, initial CABG surgery and having sinus rhythm before surgery were alternatively randomized into the study or the control group (n=80). The patients in the study group received 4 g potassium magnesium aspartate in 250 ml of 5% glucose solution infused intravenously for 3 days. Patients in the control group received 250 ml of 5% glucose solution infused intravenously for 3 days. Exclusion criteria included history of AF, implanted pacemaker, postoperative myocardial infarction, pump CABG in operation and renal failure. The end point was development of AF after operation. RESULTS: The incidence of AF was 9% in patients who received 3 days of potassium magnesium aspartate. Patients without potassium magnesium aspartate had an AF incidence of 19% (P<0.01). The ICU stay was also shorter in the treated group (P<0.05). CONCLUSION: A 3-day postoperative infusion of potassium magnesium aspartate is safe and effective in reduction of possible life-threatening AF in patients undergoing off-pump coronary artery bypass graft surgery.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2013-06-08.作者简介：郭海平，副主任医师，硕士 Email：guohaiping868@163.com
更新日期/Last Update: 2014-01-20