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|本期目录/Table of Contents|

铜川市H型高血压病患者急性脑梗死的危险因素分析

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第2期
页码:
160-162
栏目:
临床研究
出版日期:
2014-01-20

文章信息/Info

Title:
Risk factors of acute cerebral infarction in H type hypertensive patients in Tongchuan City
作者:
王成凯1; 李亚斌2; 雷华斌1; 宋昌鹏1; 王有恒1
(1.铜川市人民医院神经科，陕西 铜川727000；2.陕西省第二人民医院神经内科，陕西 西安 710005)
Author(s):
WANG Cheng-kai1;  LI Ya-bin2;  LEI Hua-bin1;  SONG Chang-peng1;  WANG You-heng1
(1.Department of Internal Neurobiology, First Tongchuan People’s Hospital, Tongchuan 727000, Shaanxi, China; 2.Department of Internal Neurobiology, Shaanxi Second People’s Hospital, Xi’an 710005, Shaanxi, China)
关键词:
高血压; 原发性; H型; 脑梗死; 急性; 危险因素; 病例对照研究
Keywords:
hypertension;  primary;  H type;  cerebral infarction;  acute;  risk factors;  case-control study
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的:调查铜川市H型高血压病患者急性脑梗死发生的危险因素。方法： 铜川市H型高血压病发生急性脑梗死确诊病例561例，进行1∶1配对进行病例对照研究，获得环境暴露等资料，采用EPI-info（6.04）和SPSS（15.0）统计软件进行单因素和多因素Logistic回归分析，计算各因素的调整比值比（OR）和95%可信限（CI）。结果： 单因素分析发现， H型高血压病的561例患者并发高脂血症、糖尿病、高C-反应蛋白血症、短暂性脑缺血发作（TIA）、肥胖、吸烟、酗酒等危险因素与急性脑梗死成正相关，差异有统计学意义（均P<0.05）。而马来酸依那普利叶酸片能降低H型高血压病患者患脑梗死的风险。多因素分析结果显示，糖尿病、高C-反应蛋白血症、重度颈动脉狭窄、TIA是H型高血压病发生急性脑梗死的主要危险因素，差异有统计学意义（均P<0.05）。结论： 铜川市H型高血压病患者急性脑梗死的独立危险因素是高C-反应蛋白血症、糖尿病、重度颈动脉狭窄、TIA，马来酸依那普利叶酸片是其保护因素。
Abstract:
AIM:To investigate the risk factors of acute cerebral infarction in type H hypertensive patients in Tongchuan City. METHODS: A 1∶1 matched case-control study was conducted in 561 cases of confirmed acute cerebral infarction diagnosed in H type hypertensive patients in Tongchuan City. EPI-info (6.04) and SPSS (15) were used for the logistic regression analysis of single and multiple factors, and the adjusted odds ratio of each factor (OR) and 95% confidence limit (CI) were calculated. RESULTS: Single factor analysis found that hyperlipidemia, diabetes, high C-reactive protein, transient ischemic attack (TIA), obesity, smoking and alcoholism were related to acute cerebral infarction. Enalapril maleate and folic acid tablets reduced the risk of acute cerebral infarction in H type hypertensive patients. Multivariate analysis showed that diabetes, high C-reactive protein, severe carotid stenosis and TIA were the main risks of acute cerebral infarction in H type hypertensive patients. CONCLUSION: The independent risk factors in H type hypertensive patients are high C-reactive protein, diabetes, severe carotid stenosis and TIA. Enalapril maleate and folic acid tablets are protective factors.

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备注/Memo

备注/Memo:
收稿日期：2013-07-22.
作者简介：王成凯，主治医师，硕士Email：wangchengkai7937@126.com
更新日期/Last Update: 2014-01-16